The effects of repeated nocturnal doses of clobazam, dipotassium chlorazepate and placebo on subjective ratings of sleep and early morning behaviour and objective measures of arousal, psychomotor performance and anxiety

British Journal of Clinical Pharmacology
I Hindmarch, A C Parrott


1. Repeated nocturnal doses of 30 mg clobazam and dipotassium chlorazepate 15 mg showed no significant effects compared to matching placebo on tests of psychomotor performance and serial subtraction of numbers given in the morning and afternoon of the day following treatment. 2. Both active preparations improved the perceived quality of sleep compared to placebo. 3. A reduction in rated anxiety scores was found with clobazam on the afternoon of the day following treatment together with an elevation of critical flicker fusion thresholds. 4. Dipotassium chlorazepate was found to impair performance of a low level conceptual task but not to influence performance at a more difficult level.


Jun 1, 1976·British Journal of Clinical Pharmacology·A N NicholsonH M Ferres
Oct 1, 1977·British Journal of Clinical Pharmacology·A N NicholsonC H Clarke
May 1, 1978·Psychological Medicine·A C Parrott, I Hindmarch
Jan 1, 1979·British Journal of Clinical Pharmacology·W RuppO Vanderbeke
Jan 1, 1979·British Journal of Clinical Pharmacology·I Hindmarch
Jan 1, 1968·Journal of Clinical Psychology·D T Johnson, C D Spielberger
Jul 1, 1972·The Journal of Clinical Pharmacology and New Drugs·J J Ricca
Dec 1, 1968·Journal of Consulting and Clinical Psychology·D T Johnson


Jan 1, 1982·Psychopharmacology·L C Johnson, D A Chernik
Oct 1, 1982·European Journal of Clinical Pharmacology·A C ParrottP D Stonier
Jan 1, 1989·European Journal of Clinical Pharmacology·C H van der MeydenL C Pretorius
Mar 15, 1980·British Medical Journal
Jan 1, 1986·Acta Psychiatrica Scandinavica. Supplementum·I Hindmarch
Aug 1, 1987·British Journal of Addiction·S D Ferrara
Aug 1, 1986·Anaesthesia·V Narang, J R Laycock
Jan 27, 2009·Journal of the American Academy of Dermatology·Kristina Callis DuffinGerald G Krueger
Jan 1, 1997·Journal of Psychopharmacology·A S WellsM D'Amato
Apr 1, 1996·Environmental Health Perspectives·A Wetherell
Oct 28, 1998·Journal of Clinical Psychopharmacology·M BourinB Guitton
Sep 1, 1980·British Journal of Clinical Pharmacology·I Hindmarch
Aug 1, 1980·British Journal of Clinical Pharmacology·I Hindmarch, A C Gudgeon

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