The effects of resiniferatoxin in an experimental rat thoracotomy model

Anesthesia and Analgesia
Jin-Woo ShinPeter Gerner

Abstract

Chronic pain after thoracotomy has been reproduced in a rat model that allows investigation of drugs that might reduce the incidence of allodynia after thoracotomy. Previous studies suggest that morphine, clonidine, neostigmine, gabapentin, and bupivacaine reduce the incidence of allodynia in the rat postthoracotomy pain model. One purpose of this study was to test whether intercostal injection of resiniferatoxin (RTX) decreased the amount of allodynia in an animal model of chronic postthoracotomy pain. We also tested whether RTX induced a transient mechanical hyperalgesic response in uninjured animals. Male Sprague-Dawley rats were anesthetized, and the right fourth and fifth ribs were surgically exposed. The pleura was opened, and the ribs were retracted. Intercostal RTX 0.8 or 8 microg was injected in animals that developed allodynia after surgery; a control group underwent rib retraction and received vehicle only. An additional group of uninjured animals received RTX. Rats were tested for mechanical allodynia at a predetermined area around the incision site for 3 wk. Allodynia developed in 42% of the animals that underwent thoracotomy. A transient hyperalgesic response was noted in the uninjured group that underwent drug in...Continue Reading

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Oct 22, 2008·Anesthesia and Analgesia·Jin Woo ShinPeter Gerner

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Citations

Oct 9, 2012·Peptides·Richard J Bodnar
Jun 18, 2011·The Journal of Pain : Official Journal of the American Pain Society·Mahendra BishnoiLouis S Premkumar
Jun 28, 2015·The Journal of Pain : Official Journal of the American Pain Society·Ching-Hsia HungGary R Strichartz
Jan 13, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M BuffiniJ F X Jones

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