The effects of resveratrol on vasospasm after experimental subarachnoidal hemorrhage in rats

Surgical Neurology
Alper KaraoglanAhmet Colak

Abstract

Cerebral vasospasm remains a major cause of morbidity and mortality in patients with SAH. Although many pharmacologic agents and chemicals have been used to prevent and treat CV, the pathogenesis of that condition has not been established. We investigated the efficacy of resveratrol, a stilbene polyphenol and tyrosine kinase inhibitor that occurs naturally in grapes and red wine, in a murine basilar artery vasospasm model. Forty-two Wistar albino rats were used in this study. The rats were divided into 3 groups of 14 animals each: the sham-operated control group (group 1), the vasospasm group (group 2), and the treatment group (group 3). In groups 2 and 3, autologous blood (0.3 mL) was injected into the cisterna magna. After that injection, the rats in group 3 received an intravenous injection of resveratrol (10 mg/kg) for 72 hours. The evaluation of the response to both the injection of autologous blood and treatment was based on biochemical markers in tissue and serum and on light microscopic findings from the basilar artery, which were collected at different intervals after experimental SAH. Endothelin-1 levels in brain tissue and serum were higher in the vasospasm group than in the control group (P < .05). In group 3 rats, ...Continue Reading

References

Feb 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S SakakiS Takeda
Apr 1, 1994·Stroke; a Journal of Cerebral Circulation·T ShishidoK Hirakawa
Nov 17, 1998·Journal of Neurosurgery·P GaetaniF Marzatico
Sep 28, 1999·British Journal of Pharmacology·Y DobrydnevaP F Blackmore
Feb 19, 2000·Life Sciences·L Frémont
Mar 13, 2001·Journal of Cardiovascular Pharmacology·L GiovanniniA Bertelli
Apr 13, 2002·Japanese Journal of Pharmacology·Richard SercombePhilippe Gomis
Jun 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Jean-Francois MarierMurray P Ducharme
Sep 7, 2002·Stroke; a Journal of Cerebral Circulation·Matthew J McGirtDavid S Warner
Nov 26, 2002·Neurosurgery·Michael ChowNeal F Kassell
Nov 19, 2003·Hypertension·Ju-Chi LiuTzu-Hurng Cheng
Jul 29, 2004·Current Medicinal Chemistry·Chih-Lung LinAij-Lie Kwan

❮ Previous
Next ❯

Citations

Oct 28, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·James M Smoliga, Otis Blanchard
Mar 8, 2014·The Journal of Surgical Research·Xiao-Ming ZhouXin Zhang
Nov 22, 2011·World Neurosurgery·Robert G WhitmoreSherman C Stein
May 11, 2010·World Neurosurgery·Onder GüneyYalcin Kocaogullar
Nov 26, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Coralia LunaPedro Gonzalez
Aug 19, 2015·Neurochemistry International·Mary S LopezRaghu Vemuganti
Jun 20, 2012·Neurochemistry International·Fabrício SimãoChristianne G Salbego
Jul 27, 2010·Journal of Neuroimmunology·Jin A ShinEun-Mi Park
Jun 22, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mary S LopezRaghu Vemuganti
Apr 20, 2011·Circulation·Jason C KovacicValentin Fuster
Apr 20, 2013·Stroke; a Journal of Cerebral Circulation·Sebastian Koch, Nestor Gonzalez
Feb 27, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Weifeng WanJiping Tang
Jun 18, 2017·Pharmacological Reports : PR·Agnieszka Wąsik, Lucyna Antkiewicz-Michaluk
Sep 9, 2019·World Neurosurgery·Ezgi AkarHakan Somay
Oct 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·In Soo PyoSung-Joon Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.