The effects of riluzole on neurological, brain biochemical, and histological changes in early and late term of sepsis in rats

The Journal of Surgical Research
Hale Z TokluMehmet Kaya

Abstract

One of the underlying mechanisms of sepsis is thought to be the oxidative damage due to the generation of free radicals. Glutamate, the major excitatory amino acid in the brain, is known to play an important role in blood brain barrier (BBB) permeability, brain edema, and oxidative damage in pathological conditions. Riluzole, a glutamate release inhibitor, has been shown to have neuroprotective effects in several animal models. The aim of our study was to investigate the putative protective effect of riluzole against sepsis-induced brain injury. Sepsis was induced by cecal ligation and puncture in Wistar albino rats. Sham operated (control) and sepsis groups received either saline or riluzole (6 mg/kg, s.c.) 30 min after the surgical procedure, and every 12 h as continuing treatment. The effect of riluzole on the survival rate, weight loss, fever, leukocyte count, brain edema, BBB permeability, oxidative damage, and histological observations were evaluated for early (6 h) and late (48 h) phase of sepsis. Riluzole, when administered 6 mg/kg s.c., diminishes the sepsis-induced augmentation in weight loss, body temperature, brain edema, increase in BBB permeability, oxidative damage, and brain injury that is observed histologicall...Continue Reading

References

May 1, 1986·Stroke; a Journal of Cerebral Circulation·J B BedersonH Bartkowski
Feb 4, 1999·Journal of Neurochemistry·J Y KohJ H Seo
Jul 13, 2000·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·T Volk, W J Kox
Aug 31, 2000·Critical Care Medicine·M C PapadopoulosE D Bennett
Apr 4, 2002·The Journal of Infectious Diseases·Pia VillaPietro Ghezzi
Apr 12, 2003·Critical Care Medicine·Ralph BogdanskiChristian Werner
Jul 8, 2003·Molecular Neurobiology·Guy C Brown, Anna Bal-Price
Oct 3, 2003·Cardiovascular Research·Kirsten PetersC James Kirkpatrick
Feb 24, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Rebecca GreenSteven Conrad
Jun 24, 2004·Best Practice & Research. Clinical Anaesthesiology·Markus A WeigandAxel Bouchon
Nov 3, 2004·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Erkan KaptanogluEtem Beskonakli
Nov 25, 2004·Neuroscience·A W UnterbergK L Kiening
Apr 27, 2005·Brain Research. Brain Research Reviews·Jerome J A HendriksChristine D Dijkstra
Jun 15, 2005·International Immunopharmacology·Göksel SenerGözde Erkanli
Mar 1, 2006·Critical Care Medicine·Tatiana BarichelloFelipe Dal-Pizzol

❮ Previous
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Citations

May 31, 2013·Annals of Intensive Care·Romain SonnevilleTarek Sharshar
Feb 7, 2009·Critical Care : the Official Journal of the Critical Care Forum·Michael A FlierlKyros Ipaktchi
Jul 16, 2014·Canadian Journal of Physiology and Pharmacology·Michal PokusaDaniela Jezova
May 27, 2009·Free Radical Research·Hale Z TokluGöksel Sener
Aug 23, 2011·Pharmacological Reports : PR·Kambiz HassanzadehSadollah Mohammadi
Aug 1, 2015·Physiology & Behavior·Dilek OzbeyliOzgur Kasimay
Aug 14, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ronan M G BergKirsten Møller
Aug 2, 2011·Brain Research·Sezen Milli AvtanBulent Ahishali
Apr 14, 2012·Brain, Behavior, and Immunity·Fabricia PetronilhoFelipe Dal-Pizzol
Aug 28, 2013·Free Radical Biology & Medicine·Rheal A TownerHugo C Castro Faria-Neto
Mar 12, 2013·Peptides·Hasan DemirEbru Akoglu
May 19, 2016·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Mehmet Serif ArslanSelcuk Otcu
Nov 5, 2016·Physiology & Behavior·Ozgur Kasimay CakirDilek Özbeyli
Apr 14, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ronan M G BergDamian M Bailey
Mar 17, 2018·Neurology India·Levente MolnárCsilla Molnár
Sep 2, 2017·The Libyan Journal of Medicine·Demet ArslanHasan Huseyin Ozdemir
Apr 6, 2018·Shock·Pedro KurtzFernando A Bozza
Sep 19, 2012·Nature Reviews. Neurology·Teneille E Gofton, G Bryan Young
Sep 15, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Figen EsenErdem Tüzün
Apr 24, 2009·Current Opinion in Neurology·Peter Pytel, Jessy J Alexander
Feb 16, 2013·Expert Review of Anti-infective Therapy·Nicolas AdamTarek Sharshar
Jan 1, 2014·Advances in Medicine·Neera Chaudhry, Ashish Kumar Duggal
Nov 26, 2016·Expert Review of Anti-infective Therapy·Simone C TauberRoland Nau
Apr 25, 2018·Molecular Neurobiology·Tatiana BarichelloFelipe Dal-Pizzol
Aug 19, 2020·International Journal of Environmental Research and Public Health·Piotr F CzempikŁukasz J Krzych
Jan 21, 2021·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Kinjal ThakorWaqar Waheed
Feb 23, 2021·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·Haizhou ZhuSwati S More
Jun 3, 2021·Pharmaceuticals·Carolina Araújo MoraesJoana Costa d'Avila

❮ Previous
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