The effects of ROS in prostatic stromal cells under hypoxic environment

The Aging Male : the Official Journal of the International Society for the Study of the Aging Male
Hailin RenXi Za

Abstract

The objective of this study is to explore the effects of reactive oxygen species (ROS) under hypoxic environment in prostatic stromal cells (PSC). To detect the expression of ROS in PSC and the tissues of benign prostatic hyperplasia (BPH) by flow cytometry; under hypoxic conditions, to observe the changes of cells growth and ROS in PSC; quantitative PCR was used to detect hypoxia inducible factor-1α (HIF-1α), androgen receptors (AR), vascular endothelial growth factor (VEGF), and interleukin-8 (IL-8) in PSC; After edaravone intervening, to examine the changes of cells growth, ROS, HIF-1α, AR, VEGF, and IL-8 under hypoxic conditions. The expression of ROS in tissues and cells which under hypoxic condition was significantly increased. 3% O2 promoted the proliferation. The HIF-1α, AR, VEGF, and IL-8 were upregulated under 3% O2. After edaravone intervening, ROS significantly decreased, HIF-1α and VEGF were downregulated, and cell proliferation declined. Hypoxia stimulates the generation of ROS, and the ROS may play a key role in BPH.

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Citations

Dec 13, 2017·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Muhammet GuzelsoyHakan Demirci
Jan 31, 2018·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Aldo E CalogeroSandro La Vignera
Feb 3, 2018·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Aldo E CalogeroSandro La Vignera
Nov 9, 2017·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Kirill KosilovSergey Loparev
Jan 9, 2021·Redox Report : Communications in Free Radical Research·Nabila JahanSicen Wang
Nov 18, 2019·Pathology, Research and Practice·Won Jin Cho, Jung-Soo Pyo
Dec 6, 2020·International Journal of Molecular Sciences·Miriam SaponaroMonica Montopoli
Jun 26, 2021·Journal of Ethnopharmacology·Do-Hyun ChoiHyun-Seok Kong

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