PMID: 7023528Apr 1, 1981Paper

The effects of salbutamol aerosol on lung function in patients with pulmonary emphysema

British Journal of Diseases of the Chest
D Bellamy, D C Hutchison

Abstract

The effects of inhaling 400 micrograms of salbutamol were compared with identical placebo inhaler in a double blind cross-over study of 20 patients with radiological evidence of pulmonary emphysema. There was a small but significant rise in the forced expiratory volume in one second (FEV1), but there was a much greater increase in vital capacity (VC), which was accompanied by a reduction in residual volume. Symptomatic improvement after salbutamol was reported by 14 of the patients and VC increased significantly in this group; there was no significant increase in VC in patients who did not prefer the active inhaler. There was no consistent change in the FEV1/VC ratio after salbutamol administration and this ratio is misleading as an indicator of bronchodilator responsiveness in patients with emphysema. Salbutamol is thus a valuable addition to treatment in patients with pulmonary emphysema and the response to treatment is best judged by measuring the improvement in VC.

Citations

Dec 10, 1988·BMJ : British Medical Journal·H ChrystynM D Peake
Jan 1, 1996·Thorax·B J Lipworth
Nov 7, 2002·Respiratory Medicine·D C S HutchisonUNKNOWN British Thoracic Society
Jun 26, 1999·Respirology : Official Journal of the Asian Pacific Society of Respirology·D H MassassoA J Woolcock
Apr 1, 1985·Australian and New Zealand Journal of Medicine·R A Silins, G E Marlin
Jan 10, 2003·The Cochrane Database of Systematic Reviews·P SestiniF S Ram
Mar 19, 2013·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·André Luis Pinto SoaresSilvia Carla Rodrigues

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