Jun 1, 1974

The effects of salbutamol and terbutaline on physiological tremor, bronchial tone and heart rate

British Journal of Clinical Pharmacology
J M Watson, A Richens

Abstract

1 The effects of oral doses of the bronchodilator drugs, salbutamol (4 and 8 mg) and terbutaline (5 and 10 mg), on physiological tremor, bronchial tone, heart rate and blood pressure were studied in six normal subjects. 2 Both drugs produced a significant increase in physiological tremor, compared with placebo. Terbutaline, but not salbutamol, produced a dose related response. No significant differences were observed between drugs. 3 Terbutaline (5 and 10 mg) and salbutamol (8 mg) produced a significant bronchodilatation compared with placebo. Dose related responses were obtained with both drugs, although this reached significance only with terbutaline. 4 Both doses of each drug produced a tachycardia, although this was only statistically significant with the high doses. 5 No significant change in blood pressure was observed with either drug. 6 Peak effects of salbutamol occurred between 1 and 3 h and terbutaline between 1 and 4 hours. Both drugs were still active at 6 hours.

  • References12
  • Citations17

Citations

Mentioned in this Paper

Bronchial System
Bronchodilator Agents
Physiological Tremor
Bronchial brand of guaifenesin-theophylline
Bronchial Specimen
Essential Tremor
Terbutaline
Blood Pressure
Bronchial Diseases
Albuterol

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