PMID: 6108996Sep 1, 1980Paper

The effects of scorpion venom toxin on the release of amino acid neurotransmitters from cerebral cortex in vivo and in vitro

Journal of Neurochemistry
J Coutinho-NettoH F Bradford

Abstract

Tityustoxin, the active component of the venom of the Brazilian yellow scorpion Tityus serrulatus, caused specific release of the neurotransmitter amino acids glutamate, aspartate and GABA in vivo from the superfused sensori-motor cortex of conscious unanesthetised rats and in vitro from rat cortical synaptosomes. The effects on synaptosomes appear to be due to a depolarising action. Synaptosomal potassium levels were depleted by the toxin. The action was also blocked both in vivo and in vitro by tetrodotoxin and was Ca2+-dependent. The uptake of [U-14C]GABA was inhibited by tityustoxin but this action was prevented by tetrodotoxin (1 microM). Since the release of [U-14C]GABA from synaptosomes due to the tityustoxin was also prevented by tetrodotoxin under identical circumstances, it is concluded that the tityustoxin has a primary action on release of neurotransmitters rather than on uptake.

References

Jul 30, 1976·Brain Research·P R Dodd, H F Bradford
Sep 20, 1976·Biochemical and Biophysical Research Communications·C D Linden, M A Raftery
Jan 1, 1976·Biochemical Society Transactions·P R Dodd, H F Bradford
May 1, 1968·Toxicon : Official Journal of the International Society on Toxinology·C R Diniz, J M Torres
Nov 1, 1974·Journal of Physics E: Scientific Instruments·P R DoddK C Blanshard
Oct 1, 1971·Toxicon : Official Journal of the International Society on Toxinology·W L TafuriJ R Cunha Melo
Nov 1, 1969·Journal of Neurochemistry·H F Bradford, A J Thomas
Jan 1, 1980·Journal of Neurochemistry·P J NorrisR H Penny

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Citations

Aug 15, 1980·Biochemical Pharmacology·A S Abdul-GhaniH F Bradford
Sep 1, 1982·Biochemical Pharmacology·D W PetersonP G Mantle
Feb 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·M R Sandoval, V A Dorce
Dec 1, 1994·Toxicon : Official Journal of the International Society on Toxinology·V A Dorce, M R Sandoval
Feb 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·Nuhan Purali
Jun 24, 1998·Toxicon : Official Journal of the International Society on Toxinology·A J FataniI J Zeitlin
Dec 1, 1983·Journal of Biomolecular Structure & Dynamics·N R KrishnaD D Watt
Jun 1, 1981·Epilepsia·J Coutinho-NettoH F Bradford
Apr 28, 2009·Brain Research Bulletin·Roberta LuongoMaria Regina Lopes Sandoval
Oct 1, 1981·Biochemical Pharmacology·A S Abdul-GhaniN J Birdsall
May 18, 2004·Brain Research. Brain Research Reviews·Wudayagiri RajendraKandiah Jeyaseelan
Jul 1, 1981·Journal of Neurochemistry·A S Abdul-GhaniE J Thompson
Jun 1, 1985·Biochemical Pharmacology·D K Norris, H F Bradford
Jul 10, 2012·Life Sciences·Luciene Toshietakeishi OssanaiValquiria Abrão Coronado Dorce
Oct 20, 2006·Toxicology and Applied Pharmacology·Alessandra L CecchiniEliane Candiani Arantes
Sep 1, 1983·Journal of Neurochemistry·C M ThankiH F Bradford

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