The Effects of Serum Proteins on Magnesium Alloy Degradation in Vitro

Scientific Reports
Ian JohnsonHuinan Liu

Abstract

Magnesium (Mg) alloys are promising materials for biodegradable implants, but their clinical translation requires improved control over their degradation rates. Proteins may be a major contributing factor to Mg alloy degradation, but are not yet fully understood. This article reports the effects of fetal bovine serum (FBS), a physiologically relevant mixture of proteins, on Mg and Mg alloy degradation. FBS had little impact on mass loss of pure Mg during immersion degradation, regardless of whether or not a native oxide layer was present on the sample surface. FBS reduced the mass loss of Mg-Yttrium (MgY) alloy with an oxidized surface during immersion degradation, but increased the mass loss for the same alloy with a metallic surface (surface oxides were removed). FBS also influenced the mode of degradation by limiting the depth of pit formation during degradation processes on commercially pure Mg with metallic or oxidized surfaces and on MgY alloy with oxidized surfaces. The results demonstrated that serum proteins had significant interactions with Mg-based biodegradable metals, and these interactions may be modified by alloy composition and processing. Therefore, proteins should be taken into account when designing experimen...Continue Reading

References

Mar 1, 1982·Journal of Biomedical Materials Research·G C Clark, D F Williams
Oct 26, 2005·Biomaterials·Mark P StaigerGeorge Dias
May 9, 2007·Clinical Oral Implants Research·Michael N SelaDavid Kohavi
May 26, 2010·Clinical Oral Implants Research·Jin-Woo ParkHwangjun Song
Nov 30, 2011·Journal of Biomedical Materials Research. Part a·Ian JohnsonHuinan Liu
Feb 5, 2013·Journal of Materials Science. Materials in Medicine·Y HedbergI Odnevall Wallinder
Jan 1, 2010·Journal of Oral & Maxillofacial Research·Ryo JimboCarina B Johansson

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Citations

Feb 2, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Kai NaritaHuinan Liu
Dec 30, 2020·Journal of Applied Biomaterials & Functional Materials·Wenjun LiPeijun Lyu
Sep 6, 2020·Acta Biomaterialia·Reneé UnbehauRegine Willumeit-Römer

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Methods Mentioned

BETA
scanning electron microscopy
x-ray spectroscopy

Software Mentioned

R

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