The effects of sevoflurane anesthesia on insulin secretion and glucose metabolism in pigs

Anesthesia and Analgesia
S SahoN Yoshimura

Abstract

We investigated the effects of two different concentrations of sevoflurane, 0.4 minimum alveolar anesthetic concentration (MAC) and 1.0 MAC, on insulin secretion before, during, and after sevoflurane anesthesia using three successive intravenous glucose tolerance tests (IVGTT) in pigs with indwelling catheters. We also investigated changes in the levels of plasma glucose, catecholamines (epinephrine [E], norepinephrine [NE]), and cortisol (Cor). The pigs were grouped as awake, 0.4 MAC, or 1.0 MAC. Sevoflurane decreased the ratio of insulin/glucose (INS/GLU) in the basal condition (P < 0.05 awake versus 1.0 MAC) and during IVGTT (P < 0.01 awake versus 1.0 MAC and 0.4 MAC). These decreases were quickly reversible (control levels were regained within 2 h of the end of anesthesia), were probably dose-related, appeared not to be mediated by E, NE, or Cor. In addition, the INS/GLU ratio 2.5-4 h after the end of anesthesia was significantly higher in the anesthetized groups than in the awake group. We conclude that sevoflurane anesthesia has a rapidly reversible inhibitory effect on basal and glucose-stimulated insulin secretion, as do other inhaled anesthetics, and might induce insulin resistance.

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Citations

May 8, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T SchrickerM Georgieff
Oct 5, 2011·Surgery Today·Akira HasegawaTakayuki Noguchi
May 25, 2010·Journal of Nutritional Science and Vitaminology·Masahiro KanazawaToshiyasu Suzuki
Jan 1, 2013·Biochemical and Biophysical Research Communications·Yoshikazu YasudaJ A Jeevendra Martyn
Oct 6, 2004·Best Practice & Research. Clinical Anaesthesiology·Heidi J RobertshawGeorge H Hall
May 24, 2016·Anesthesia, Essays and Researches·Manoj KumarAmit Tyagi
Mar 10, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Haiyun QiChristoffer Laustsen
Oct 22, 2009·Anesthesia and Analgesia·Takayuki KitamuraYoshitsugu Yamada
Jan 19, 2010·Anesthesia and Analgesia·Shamsuddin AkhtarSilvio E Inzucchi
Apr 17, 2012·Anesthesia and Analgesia·Takashi KawanoMasataka Yokoyama
Mar 17, 2004·Journal of Neurosurgical Anesthesiology·Jeffrey J PasternakWilliam L Lanier

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