The effects of sevoflurane, isoflurane, halothane, and enflurane on hemodynamic responses during an inhaled induction of anesthesia via a mask in humans

Anesthesia and Analgesia
S TanakaA Namiki

Abstract

A rapid increase in isoflurane or desflurane concentration induces tachycardia and hypertension and increases-plasma catecholamine concentration. Little information is available as to whether sevoflurane, halothane, and enflurane induce similar responses during anesthesia induction via mask. Fifty ASA physical status I patients, aged 20-40 yr, and scheduled for elective minor surgery, received one of four volatile anesthetics: sevoflurane, isoflurane, halothane, or enflurane. Anesthesia was induced with thiamylal, followed by inhalation of 0.9 minimum alveolar anesthetic concentration (MAC) of the anesthetic in 100% oxygen via mask. The inspired concentration of anesthetic was increased by 0.9 MAC every 5 min to a maximum of 2.7 MAC. Heart rate (HR) and systolic blood pressure (SBP) were measured before and every minute for 15 min during anesthetic inhalation. In the sevoflurane and isoflurane groups, venous blood samples were drawn to determine the concentrations of plasma epinephrine and norepinephrine 3 min after each increase in anesthetic concentration. Sustained increments in HR were observed after increases in inspired isoflurane concentration to 1.8 MAC and 2.7 MAC (peak changes of 15 +/- 3 and 17 +/- 3 bpm, respectivel...Continue Reading

References

Jan 1, 1992·Anesthesia and Analgesia·P F ConzenK Messmer
Mar 1, 1987·Anesthesiology·T Katoh, K Ikeda
Oct 31, 1974·The New England Journal of Medicine·A P Fishman, G G Pietra
Oct 1, 1971·Anesthesiology·H Gion, L J Saidman
Feb 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M Doi, K Ikeda

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Citations

Nov 8, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M NakayamaA Namiki
Aug 29, 2006·Surgery Today·Tsukasa IsagoHiroaki Nakazawa
Jun 29, 2002·Journal of Clinical Anesthesia·Tomoki NishiyamaKazuo Hanaoka
Aug 7, 2007·Journal of Cardiothoracic and Vascular Anesthesia·Giovanni LandoniGiorgio Torri
Mar 7, 2002·British Journal of Anaesthesia·O PickerJ O Arndt
Mar 23, 2002·International Anesthesiology Clinics·Kyung W Park

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