The effects of sex and hormonal status on restraint-stress-induced working memory impairment

Behavioral and Brain Functions : BBF
Rebecca M ShanskyAmy F T Arnsten

Abstract

Restraint stress has been shown to elicit numerous effects on hippocampal function and neuronal morphology, as well as to induce dendritic remodeling in the prefrontal cortex (PFC). However, the effects of acute restraint stress on PFC cognitive function have not been investigated, despite substantial evidence that the PFC malfunctions in many stress-related disorders. The present study examined the effects of restraint stress on PFC function in both male rats and cycling female rats in either the proestrus (high estrogen) or estrus (low estrogen) phase of the estrus cycle. Animals were restrained for 60 or 120 minutes and then tested on spatial delayed alternation, a PFC-mediated task. Performance after stress was compared to performance on a different day under no-stress conditions, and analyzed using analysis of variance (ANOVA). Sixty minutes of restraint impaired only females in proestrus, while 120 minutes of restraint produced significant impairments in all animals. Increases in task completion times did not affect performance. These results demonstrate an interaction between hormonal status and cognitive response to stress in female rats, with high estrogen levels being associated with amplified sensitivity to stress. T...Continue Reading

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Citations

Dec 21, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Emil Trofimiuk, Jan J Braszko
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Avis Brennan HainsAmy F T Arnsten
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Jan 24, 2018·The European Journal of Neuroscience·Michael V BarattaSteven F Maier
May 10, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Naghmeh ShafieiStan B Floresco
Feb 3, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Courtney A Bryce, Stan B Floresco
Dec 18, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Colin D ReyRebecca M Shansky
Jul 29, 2018·Nature Reviews. Neuroscience·Robert J FensterJunghyup Suh
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May 21, 2009·Nature Reviews. Neuroscience·Amy F T Arnsten
Sep 26, 2015·Nature Neuroscience·Amy F T Arnsten
Nov 14, 2008·Stress : the International Journal on the Biology of Stress·Rebecca M ShanskyA F T Arnsten
Feb 2, 2021·Neurobiology of Stress·Mona FariborziGyorgy Lur
Apr 17, 2021·Consciousness and Cognition·Yuecui KanHaijun Duan
Jul 12, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Milena GirottiDavid A Morilak
Jul 3, 2016·Neuroscience and Biobehavioral Reviews·Grant S ShieldsAndrew P Yonelinas

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Methods Mentioned

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Software Mentioned

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