The effects of short-term and long-term testosterone supplementation on blood viscosity and erythrocyte deformability in healthy adult mice

Endocrinology
Wen GuoShalender Bhasin

Abstract

Testosterone treatment induces erythrocytosis that could potentially affect blood viscosity and cardiovascular risk. We thus investigated the effects of testosterone administration on blood viscosity and erythrocyte deformability using mouse models. Blood viscosity, erythrocyte deformability, and hematocrits were measured in normal male and female mice, as well as in females and castrated males after short-term (2 wk) and long-term (5-7 mo) testosterone intervention (50 mg/kg, weekly). Castrated males for long-term intervention were studied in parallel with the normal males to assess the effect of long-term testosterone deprivation. An additional short-term intervention study was conducted in females with a lower testosterone dose (5 mg/kg). Our results indicate no rheological difference among normal males, females, and castrated males at steady-state. Short-term high-dose testosterone increased hematocrit and whole-blood viscosity in both females and castrated males. This effect diminished after long-term treatment, in association with increased erythrocyte deformability in the testosterone-treated mice, suggesting the presence of adaptive mechanism. Considering that cardiovascular events in human trials are seen early after i...Continue Reading

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Citations

Dec 23, 2016·Der Internist·T KoflerM Trendelenburg
May 28, 2019·Nature Reviews. Cardiology·Thiago Gagliano-Jucá, Shehzad Basaria
Aug 3, 2017·American Journal of Physiology. Endocrinology and Metabolism·Laura G GoetzHugh S Taylor
Jun 23, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zelal Jaber KharabaYassen Alfoteih

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