The effects of short-term immobilization stress on muscarinic receptors, beta-adrenoceptors, and adenylyl cyclase in different heart regions

Annals of the New York Academy of Sciences
J MyslivecekRichard Kvetnansky

Abstract

Heart muscarinic receptors (MR) and beta-adrenoceptors (BAR) belong to a large family of G-protein-coupled receptors. Although the role of catecholamines in the stress has been under keen investigation for many years, the effects of immobilization on this pair of receptors, considering their almost completely opposite actions in the heart, are not yet known. We have studied the effects of short-term immobilization (for 120 min) with different times of decapitation after the end of the immobilization period (0, 3, and 24 h) on MR, BAR (beta(1)-AR and beta(2)-AR using radioligand binding studies), and adenylyl cyclase (AC; using high-pressure liquid chromatography detection of cAMP) in different heart regions (left and right atria with or without cardiac ganglion cells [auriculae], septum, and left and right ventricles). The effects of one immobilization period were first apparent after 24 h. Stress brought about a downregulation of MR and BAR with decrease in AC activity. These effects were regionally specific and were predominantly expressed in the right atria, which is rich in ganglia cells, and in the right ventricles. Our results indicate that stressful stimuli can influence not only BAR, but MR, and that AC activity can als...Continue Reading

References

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Citations

Apr 30, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Jaromir MyslivecekJan Ricny
Sep 22, 2009·Canadian Journal of Physiology and Pharmacology·Adriana AdameovaNaranjan S Dhalla
May 22, 2007·Stress : the International Journal on the Biology of Stress·O KrizanovaL Kubovcakova
Aug 2, 2006·Autonomic & Autacoid Pharmacology·J Myslivecek, R Kvetnanský
Jul 24, 2013·Stress and Health : Journal of the International Society for the Investigation of Stress·Marcela LaukovaJaromir Myslivecek
Jan 15, 2015·Stress : the International Journal on the Biology of Stress·Hana TomankovaJaromir Myslivecek
Jan 6, 2009·Annals of the New York Academy of Sciences·Andrej TillingerRichard Kvetnanský
Jan 6, 2009·Annals of the New York Academy of Sciences·Jaromir MyslivecekRichard Kvetnanský
Aug 10, 2006·Stress : the International Journal on the Biology of Stress·Iraídes N Santos, Regina C Spadari-Bratfisch
Jun 4, 2020·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Mengyang YuShike Hou
Oct 25, 2017·Cellular and Molecular Neurobiology·Regina Celia SpadariPaula Frizera Vassalo

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