The effects of short-term oral phytoestrogen supplementation on the hypothalamic-pituitary-testicular axis in prostate cancer patients

The Prostate
Antti RannikkoHerman Adlercreutz

Abstract

Here we evaluate the effects of oral phytoestrogen supplementation on hypothalamic-pituitary-testicular (HPT) axis in CaP patients. We recruited 40 men about to undergo radical prostatectomy for CaP to receive either 240 mg of clover phytoestrogens or placebo daily for 2 weeks. Serum hormone levels were measured before and after treatment. In addition, recombinant cell bioassay was used to measure serum androgen bioactivity (ABA). Phytoestrogen treatment increased serum LH from mean of 3.4-5.2 IU, P = 0.03. Concomitantly, non-significant trend towards decline in serum T, cfT and ABA values was noted. However, mean serum LH/T ratio was upregulated from 0.20 to 0.48 IU/nM, P = 0.004, suggesting compensated hypogonadism. During the course of treatment, serum concentration of equol correlated strongly with the concomitant decrease in ABA (r = -0.586, P = 0.022). Phytoestrogen treatment interferes with HPT axis in CaP patients by inducing testicular resistance to LH and compensated hypogonadism.

References

Nov 15, 1977·International Journal of Cancer. Journal International Du Cancer·N BreslowH Tulinius
Jul 1, 1988·Developmental Biology·A A Donjacour, G R Cunha
May 1, 1984·Journal of the American Geriatrics Society·R Horton
Oct 1, 1982·Scandinavian Journal of Clinical and Laboratory Investigation·E Hämäläinen
Jun 1, 1981·The Journal of Endocrinology·O KaplanskiA Berman
Mar 10, 1998·Proceedings of the Society for Experimental Biology and Medicine·H Adlercreutz
Feb 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T ShaneyfeltC S Mantzoros
Feb 13, 2001·Molecular and Cellular Endocrinology·A KrazeisenJ Adamski
Oct 9, 2001·Epidemiologic Reviews·A W Hsing, S S Devesa
Jan 5, 2002·International Journal of Cancer. Journal International Du Cancer·Paola PisaniD Maxwell Parkin
Jul 11, 2002·The Lancet Oncology·Herman Adlercreutz
Dec 7, 2002·The Journal of Nutrition·Kenneth D R SetchellEva Lydeking-Olsen
Mar 20, 2003·Current Drug Targets·Colm Morrissey, R William G Watson
Jun 11, 2003·Nutrition Reviews·Mark J Messina
Jun 26, 2003·The New England Journal of Medicine·Ian M ThompsonCharles A Coltman
Dec 19, 2003·Biology of Reproduction·Trent D LundRobert J Handa
Mar 26, 2004·The Prostate·Nagi B KumarJulio Pow-Sang
Dec 9, 2004·Current Opinion in Urology·Jeffrey M HolzbeierleinJ Brantley Thrasher
Jun 1, 2005·Trends in Endocrinology and Metabolism : TEM·Zhi Chao Dang, Clemens Lowik
Jun 30, 2005·The Journal of Clinical Endocrinology and Metabolism·Matti HeroTaneli Raivio
Sep 1, 2005·Prostate Cancer and Prostatic Diseases·G A SonnM S Litwin

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Citations

Jun 25, 2008·The British Journal of Nutrition·Claudia SteinerClaudine Manach
Jul 8, 2008·Urology·Jessica Clement, Glenn Bubley
Jun 21, 2007·Molecular Nutrition & Food Research·Jian-Ping YuanXin Liu
Sep 1, 2016·Molecular and Cellular Endocrinology·Michaël R LaurentFrank Claessens
Aug 26, 2009·Der Urologe. Ausg. A·T Otto

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