PMID: 8614245Mar 3, 1995Paper

The effects of sigma ligands on protein release from lacrimal acinar cells: a potential agonist/antagonist assay

Life Sciences
R D SchoenwaldE Xia

Abstract

Sigma receptor antagonists have been proposed as leading clinical candidates for use in various psychotic disorders. Prior to clinical testing, it is imperative that a new agent be correctly identified as an antagonist and not an agonist since the latter may worsen the psychosis. For sigma-ligands many behavioral and pharmacological assays have been developed in an attempt to classify agonist/antagonist activity. These assays evaluate a response or a behavior in an animal model that can be related to clinical efficacy. However, is the action by the presumed antagonist a consequence of sigma-receptor activity? Previously we have identified sigma-receptors in acinar cells of the main lacrimal gland of the New Zealand white rabbit and have measured protein release after the addition of various N,N-disubstituted phenylalkylamine derivatives known to be sigma-ligands by receptor binding studies. Although protein release from acinar cells has been attributed to either muscarinic or alpha-adrenergic stimulation, protein release from sigma-receptor stimulation was also confirmed. In the reported studies here, we isolated and incubated acinar cells with varying concentrations of known sigma-ligands and measured protein concentration. A ...Continue Reading

Citations

Oct 6, 2001·Survey of Ophthalmology·H Brewitt, F Sistani
Apr 1, 1997·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·R D SchoenwaldC F Barfknecht
Jul 22, 1998·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·R D SchoenwaldC F Barfknecht
Jan 1, 1997·Neuropharmacology·H C AkunneT G Heffner
Oct 6, 2001·Survey of Ophthalmology·C Baudouin
Jul 3, 2021·International Journal of Molecular Sciences·Francesca Serena AbatematteoCarmen Abate

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