The Effects of Simvastatin on Ischemia Reperfusion Injury in an Experimental Colon Anastomosis Model

The Indian Journal of Surgery
Mahmut AkarsuFaruk Metin Comu

Abstract

Anastomotic leakage is more frequently reported in colonic anastomoses. Ischemia reperfusion injury is one of the main reasons for anastomotic leakage. Simvastatin is known to prevent tissue damage induced by free oxygen radicals after ischemia reperfusion injury. The effect of simvastatin on colonic anastomosis impaired by ischemia reperfusion injury is investigated. Single layer, end-to-end colocolic anastomosis after 0.5-cm colon resection was performed in Wistar Albino rats. In Group 1 (control) (n = 10), colonic anastomosis without I-R was performed. In Group 2 (n = 10), the superior mesenteric artery was clamped for 10 min followed by 60 min of reperfusion after which resection anastomosis was performed. In Group 3 (n = 10), 10 mg/kg simvastatin was given by gavage for 7 days after I-R and resection anastomosis. In Group 4 (n = 10), the rats received 10 mg/kg simvastatin by gavage 7 days before and 7 days after ischemia reperfusion and surgery. All of the rats were sacrificed 8 days after surgery. Anastomotic bursting pressure and tissue hydroxyproline levels were measured. Postoperative administration of simvastatin restored the anastomotic bursting pressure and hydroxyproline levels to that of control group thus overcom...Continue Reading

References

Jan 1, 1995·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A CorsiniA L Catapano
Jan 31, 1997·International Journal of Cardiology·S R Maxwell, G Y Lip
Nov 17, 1998·American Journal of Surgery·M A KuzuA H Elhan
Aug 10, 2000·Journal of the American College of Cardiology·D FerroF Violi
Apr 30, 2002·Digestive Surgery·P B SoetersC G M I Baeten
Oct 16, 2002·Circulation·David J Lefer
Oct 16, 2002·Circulation·Diethard PrueferMichael Buerke
Dec 11, 2002·Kidney International·Luis Miguel Blanco-ColioJesús Egido
Jan 22, 2003·Biochemical and Biophysical Research Communications·Motoki TakenakaOsamu Kozawa
Jan 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bernard P LeungIain B McInnes
Sep 21, 2004·Microsurgery·Maria Siemionow, Emrah Arslan
Dec 1, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Anetta UndasKenneth G Mann
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·James K Liao, Ulrich Laufs
Oct 20, 2005·Current Opinion in Cardiology·Paolo Calabrò, Edward T H Yeh
Dec 13, 2005·Nature Reviews. Cancer·Marie-France DemierreScott M Lippman
Feb 9, 2006·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·S NomuraK Hamano
Mar 23, 2006·World Journal of Gastroenterology : WJG·Suna GuzelOzgur Mutlu
Feb 17, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Nicola FerriAlberto Corsini
May 17, 2007·Acta Cirúrgica Brasileira·Amália Cínthia Meneses do RegoAldo Cunha Medeiros
Jun 25, 2008·International Archives of Allergy and Immunology·Shin-ichiro KagamiHiroshi Nakajima
Jul 7, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·G Karadeniz CakmakM Comert
May 22, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Benjamin D ShoganKonstantin Umanskiy
Jul 4, 2013·World Journal of Emergency Surgery : WJES·David CzeigerGad Shaked
May 8, 2015·Science Translational Medicine·Benjamin D ShoganJohn C Alverdy
Dec 15, 2015·Frontiers in Cardiovascular Medicine·Katarzyna GoszczIan L Megson

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.