PMID: 9547437Apr 21, 1998Paper

The effects of simvastatin on the incidence of heart failure in patients with coronary heart disease

Journal of Cardiac Failure
John KjekshusK Pyörälä

Abstract

Although treatment of myocardial overload effectively reduces death from progression of heart failure, it is not known whether the retardation of progressive coronary artery disease obtained with lipid lowering treatment will prevent the onset and consequences of heart failure in patients without previous symptoms of heart failure. In the Scandinavian Simvastatin Survival Study, 4444 patients with coronary heart disease without evidence of heart failure were randomized to placebo (n = 2223) or simvastatin 20-40 mg (n = 2221) and followed for more than 5 years. Among the patients who received placebo, 228 (10.3%) were diagnosed with heart failure during follow-up evaluation compared with 184 (8.3%) of patients who received simvastatin (P < .015). Mortality was 31.9% in the placebo group and 25.5% in the simvastatin group among patients who developed heart failure. These compare with 9.2 and 6.6%, respectively, among non-heart failure patients. There were 45 hospitalizations because of acute heart failure in the placebo group and 23 in the simvastatin group (NS). Patients who developed heart failure were more likely to have suffered a recurrent myocardial infarction and have a history of diabetes, peripheral artery disease, and h...Continue Reading

References

Aug 1, 1991·The New England Journal of Medicine·UNKNOWN SOLVD InvestigatorsJay N Cohn

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Citations

Dec 8, 2005·Current Heart Failure Reports·Kevin L Thomas, Eric J Velazquez
Dec 8, 2010·Cardiovascular Drugs and Therapy·Kristopher S LyonsMark T Harbinson
Aug 19, 2007·Heart Failure Reviews·Sofia G TsouliMoses S Elisaf
Dec 10, 2003·Current Atherosclerosis Reports·Jean Davignon
Feb 21, 2009·Current Atherosclerosis Reports·Kumudha Ramasubbu, John A Farmer
Aug 12, 2009·Current Atherosclerosis Reports·Tamara Horwich
Jul 23, 2005·Current Heart Failure Reports·Anique Ducharme, Jean Lucien Rouleau
Dec 2, 2009·Current Heart Failure Reports·Helene Glassberg
Sep 10, 2013·Current Heart Failure Reports·Justin L Grodin, W H Wilson Tang
Feb 8, 2011·Current Hypertension Reports·Krishna K GaddamCarl J Lavie
Mar 26, 2013·European Journal of Pharmacology·Masafumi KumazakiAkio Fujimura
Aug 17, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Viviane M ConraadsChristiaan J Vrints
Oct 7, 2005·International Journal of Cardiology·Reiko NakayaJong-Dae Lee
Oct 18, 2003·The American Journal of Medicine·Robert DiBianco
May 4, 2001·The American Journal of Medicine·E J Eichhorn
Aug 26, 1998·Progress in Cardiovascular Diseases·J G Cleland
Oct 19, 2000·Lancet·M RauchhausS D Anker
Jul 18, 2003·Lancet·Henry Krum, Richard E Gilbert
Dec 6, 2000·International Journal of Cardiology·M RauchhausS D Anker
May 22, 2002·Journal of the American College of Cardiology·Henry Krum, John J McMurray
Nov 26, 2002·Journal of the American College of Cardiology·Chloe A Allen MaycockUNKNOWN Intermountain Heart Collaborative Study
Jul 2, 2011·Expert Reviews in Molecular Medicine·Karen E Porter, Neil A Turner
Mar 24, 2007·Nature Clinical Practice. Cardiovascular Medicine·Michael J LipinskiGeorge W Vetrovec
Nov 10, 2010·Nature Reviews. Cardiology·Anh L BuiGregg C Fonarow
Apr 30, 2005·Seminars in Vascular Medicine·Seema Mital, James K Liao
Nov 21, 2008·Cardiovascular Research·Ulf LandmesserHelmut Drexler
Jun 30, 2011·European Heart Journal·UNKNOWN European Association for Cardiovascular Prevention & RehabilitationUNKNOWN ESC Committee for Practice Guidelines (CPG) 2008-2010 and 2010-2012 Committees
Feb 24, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M W Rich
Jun 27, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Wilbert S Aronow
Apr 13, 2004·Journal of Cardiovascular Pharmacology·Seena S AbrahamSeema Mital
Nov 9, 2005·Current Opinion in Lipidology·Michael PhamJohn C Giacomini
Aug 20, 2011·International Journal of Clinical Practice·N Verma, V M Figueredo
Dec 5, 2003·Postgraduate Medical Journal·D B McKenzie, A J Cowley
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·James K Liao, Ulrich Laufs
May 25, 2005·Current Controlled Trials in Cardiovascular Medicine·Bengt FellströmUNKNOWN AURORA Study Group
Dec 1, 2009·Cardiovascular Ultrasound·Jack RubinsteinGeorge S Abela
Mar 25, 2005·Journal of Negative Results in Biomedicine·Nusrat ShafiqAnil Grover
Jan 19, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuhiro MaejimaUNKNOWN Heart Failure by Coadministration of Statin and Angiotensin-II Receptor Blocker (HF-COSTAR) Trial Investigators
Aug 29, 2006·PLoS Medicine·Pim van der HarstDirk J van Veldhuisen
Jun 29, 2013·Vascular Health and Risk Management·Kwadwo Osei BonsuDaniel Diamond Reidpath

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