The effects of single L-amino acid substitutions on the lethal potencies of the microcystins

Toxicon : Official Journal of the International Society on Toxinology
R D StonerH W Siegelman

Abstract

Microcystin-LR and -LA are more toxic than microcystin-LY and -RR in adult mice. They induce different degrees of thrombocytopenia and leukopenia, and the lethalities of their binary and ternary mixtures are addictive. Postnatal mice are resistant to doses of microcystin-LR that are lethal to adults but they are susceptible to higher doses. Substitution of a single L-amino acid for another in a microcystin markedly affects the dosimetric potency, but not the pathophysiology of its toxicity.

References

Nov 1, 1988·Toxicology and Applied Pharmacology·W H AdamsH W Siegelman
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·R KfirD P Botes
Jan 1, 1985·Toxicon : Official Journal of the International Society on Toxinology·W H AdamsH W Siegelman
Jun 24, 1983·Science·D N SlatkinH W Siegelman
Mar 1, 1959·Canadian Journal of Biochemistry and Physiology·C T BISHOPP R GORHAM

❮ Previous
Next ❯

Citations

Dec 31, 2011·Environmental Science and Pollution Research International·Reddithota J KrupadamRajasekhar Balasubramanian
Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·R D StonerH W Siegelman
Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·K HaradaM Nakano
Nov 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·M NamikoshiK L Rinehart
Mar 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·F KondoM Suzuki
May 2, 2001·Journal of Chromatography. a·L A Lawton, C Edwards
Jun 1, 2001·Toxicon : Official Journal of the International Society on Toxinology·J McElhineyC Leifert
Aug 5, 1998·Toxicon : Official Journal of the International Society on Toxinology·R M Dawson
Nov 14, 1997·Bioorganic & Medicinal Chemistry·J E SheppeckA R Chamberlin
Mar 15, 2005·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Ronald W ZurawellEllie E Prepas
Jul 14, 2010·Environmental Pollution·Francisca F del Campo, Youness Ouahid
Jun 3, 2014·European Journal of Mass Spectrometry·Stella Bortoli, Dietrich A Volmer
Jun 29, 2018·Journal of Water and Health·James McCordNeil Chernoff
Aug 8, 1994·FEBS Letters·S Rudolph-BöhnerL Moroder
Dec 11, 2019·Toxins·Noureddine BouaïchaTri Nguyen-Quang
Jul 3, 2020·Chemical Research in Toxicology·Celine M SchreidahAjith Karunarathne

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.