The Effects of Six-Month L-Thyroxine Treatment on Cognitive Functions and Event-Related Brain Potentials in Children with Subclinical Hypothyroidism

Journal of Clinical Research in Pediatric Endocrinology
Özlem SangünBumin Dündar

Abstract

The aim of this study was to investigate the cognitive status of children with subclinical hypothyroidism (SH) before and after L-thyroxine (L-T4) treatment using event-related potentials (ERPs) and neuropsychological tests. This prospective study was conducted on a series of 20 children with mild SH (free T4 normal and thyroid-stimulating hormone level within 5-10 µIU/L) who underwent clinical and cognitive assessment before L-T4 treatment and 6 months afterwards. The recordings of ERPs were done at the time of diagnosis and after 6 months of euthyroid state. Neuropsychiatric tests for attention, perception, close and remote memory were performed on all patients and on the control group which consisted of 20 healthy children of normal intelligence. While pretreatment verbal memory (VM) and verbal recall (VR) scores of the SH group were significantly lower than those of the control group (p=0.004 and 0.012, respectively), no significant differences between the post-treatment and control groups were found in these scores after 6 months of L-T4 treatment. Post-treatment VM and VR scores were significantly higher than the pretreatment scores in the SH group (p=0.008 and p=0.0001). There were no significant differences between the ...Continue Reading

Citations

Apr 22, 2017·The Journal of Clinical Endocrinology and Metabolism·Jenica McMullenLeonardo Trasande
Sep 26, 2017·Thyroid : Official Journal of the American Thyroid Association·Ibrahim ÖnsesverenTim I M Korevaar
Jun 14, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Sibel Kocaaslan AtliBumin Nuri Dündar
Feb 1, 2020·The Journal of Clinical Endocrinology and Metabolism·Donatella CapalboMariacarolina Salerno
Dec 14, 2018·Journal of Neurosurgery·Alana Tooze, Jason P Sheehan

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