The effects of sleep on neurons in isolated cerebral cortex

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
B D BurnsA C Webb

Abstract

Slabs of cat parietal cortex with some 2 mm of underlying white matter were surgically isolated from the rest of the nervous system, without interference with the superficial blood supply. Wire micro-recording electrodes were inserted into the isolated cortex; bone, muscle and skin wounds were repaired and the animal allowed to recover from anaesthesia. The adequacy of surgical isolation was examined histologically 8--12 weeks after operation. Only one of the six preparations reported here showed surviving neural connections with the rest of the brain. Soon after operation, spontaneous bursts of neural activity appeared within the isolated area. These became more frequent until neural discharge was continuous but irregular. Our records were made from this time onwards. The interval distributions obtained from neurons within the isolated area did not differ significantly from log-normal curves. When the unrestrained animal fell asleep, there was no significant alteration in the model interval or geometric standard deviation of interval distributions recorded from cells in isolated cortex. The interval distributions of neurons in isolated cerebral cortex resembled those of neurons in the intact cortex of an alarmed animal. It is ...Continue Reading

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Citations

Jan 1, 1976·Progress in Neurobiology·R R Drucker-Colín, C W Spanis
Oct 15, 1976·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B D Burns, A C Webb
Oct 15, 1976·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A C Webb
Oct 15, 1976·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A C Webb
Jan 15, 1979·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B D Burns, A C Webb
Jul 1, 1977·Annals of Neurology·F Bremer
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Related Concepts

Cortex Bone Disorders
Adrenal Cortex Diseases
Isolation Aspects
Sleep, Slow-Wave
Entire Nervous System
Neurons
Brain
Initial Insomnia
Anesthesia Procedures
Injury Wounds

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