PMID: 9664693Jul 17, 1998Paper

The effects of social structure, geographical structure, and population size on the evolution of mitochondrial DNA: II. Molecular clocks and the lineage sorting period

Journal of Molecular Evolution
G A HoelzerDon J Melnick

Abstract

Evolutionary geneticists have increasingly used sequence variation in mitochondrial DNA (mtDNA) as a source of historical information. However, conclusions based on these data remain tentative because a sufficiently clear understanding of the evolutionary dynamics of mtDNA has yet to be developed. In this paper we present the results of computer simulations designed to illustrate the effects of social structure, geographical structure, and population size on the rate of nucleotide substitution and lineage sorting of mtDNA. The model is based in part on the social structure of macaque monkeys. Simulated populations of females were divided into 25 social groups; the animals in each were distributed in a hierarchy of four dominance rank categories. The probabilities for offspring survivorship were varied among dominance ranks to reflect the fitness consequences of social structure. Population size was varied across runs from 100 to 300 females. The pattern of female migration was also varied to mimic either the island model or the stepping-stone model. All these variables are shown to affect the lineage sorting period (LSP), and certain combinations of parameter values can cause the retention of mtDNA polymorphisms for a very long...Continue Reading

Citations

Oct 16, 1999·British Journal of Haematology·O Castro
Apr 11, 2008·Molecular Biology and Evolution·Shigeki NakagomeRyuichi Masuda
Sep 27, 2000·Evolution; International Journal of Organic Evolution·J Wakeley
Oct 3, 2001·Evolution; International Journal of Organic Evolution·B J EvansD J Melnick
Jul 11, 2009·BMC Evolutionary Biology·Yu-Chung ChiangTy Chiang
Feb 14, 2014·International Journal of Primatology·G H KoppD Zinner
May 15, 2007·Molecular Phylogenetics and Evolution·Nicolas HubertJean-François Renno
Mar 27, 2007·Molecular Phylogenetics and Evolution·Gonzalo Nieto Feliner, Josep A Rosselló
Sep 25, 2003·Evolution; International Journal of Organic Evolution·Ben J EvansDon J Melnick
Aug 5, 2003·Evolution; International Journal of Organic Evolution·Anthony J TosiDon J Melnick
May 22, 2009·Molecular Ecology·Laurie S Stevison, Michael H Kohn
May 6, 2006·Journal of Evolutionary Biology·A Harlin-CognatoR L Honeycutt
Nov 28, 2006·Molecular Phylogenetics and Evolution·M S AscunceM D Mudry
Nov 21, 2000·Molecular Phylogenetics and Evolution·A J TosiD J Melnick
Oct 18, 2000·The Journal of Psychology·S K Opt, D A Loffredo
Aug 12, 2020·Journal of Human Evolution·Ben J EvansMatthias Meyer

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