PMID: 3770448Jul 1, 1986Paper

The effects of sodium ipodate (ORAgrafin) on thyroid function in rainbow trout, Salmo gairdneri

General and Comparative Endocrinology
D G Cyr, J G Eales

Abstract

Immature rainbow trout held at 12 +/- 1 degree were injected intraperitoneally with a fine saline suspension of sodium ipodate (5 mg/100 g body wt) every 3 days. Plasma 3,5,3'-triiodo-L-thyronine (T3) fell to 40% of control levels by Day 1 and remained at about this level for the duration of the study (22 days). Plasma L-thyroxine (T4) level was not altered on Day 1 but was lowered to 50% of control values by Days 7 and 22. Immersion of trout in T4 (2 micrograms/100 ml water) elevated plasma T4 but did not alter the ipodate suppression of plasma T3. Injection of control or ipodate-treated trout with [125I]T4, [125I]T3, or Na131I indicated that in addition to blocking T45'-monodeiodination to T3, ipodate also decreased plasma clearance of T4 and T3 and their removal by the bile. Ipodate did not alter the hepatosomatic index but did depress the hematocrit by 22 days, possibly due to the hypothyroid state. In conclusion, ipodate at a dose of 5 mg/100 g, approximately one-tenth of a lethal dose, is an effective acute and chronic hypothyroid agent to administer to trout.

References

Jan 1, 1978·Vision Research·D M Allen, M Cristy
Dec 1, 1976·The Journal of Clinical Endocrinology and Metabolism·H BürgiT Lemarchand-Béraud
Oct 1, 1985·The Journal of Clinical Endocrinology and Metabolism·D C ShenD H Solomon
Jun 1, 1983·General and Comparative Endocrinology·J G EalesS Shostak
Jul 1, 1983·General and Comparative Endocrinology·J G Eales, S Shostak
Mar 1, 1982·The Journal of Clinical Endocrinology and Metabolism·S Y WuP C Chu
Oct 1, 1981·General and Comparative Endocrinology·J G Eales, R J Omeljaniuk
May 1, 1980·The Journal of Clinical Investigation·J V FelicettaW B Nelp
Sep 1, 1986·Fish Physiology and Biochemistry·J G EalesR F Cook

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