The effects of soluble-fiber polysaccharides on the adsorption of a hydrophobic carcinogen to an insoluble dietary fiber

Nutrition and Cancer
P J HarrisL R Ferguson

Abstract

Dietary fiber is believed to decrease the incidence of colorectal cancer, but not all types of fiber are equally protective. Dietary fibers may be divided broadly into insoluble and soluble fibers, and there is evidence from animal experiments that the latter not only fails to protect against colorectal cancer but may enhance its development. Adsorption of carcinogens to insoluble dietary fiber in the intestinal tract is one of the mechanisms by which dietary fiber is believed to protect against colorectal cancer. In previous in vitro experiments, we showed that the hydrophobic carcinogen 1,8-dinitropyrene (DNP) adsorbs to insoluble plant cell wall components (insoluble dietary fibers). Soluble polysaccharides (pectic polysaccharides) extracted from the walls of parenchyma cells of dicotyledonous plants were found to maintain DNP in aqueous solutions and decrease its adsorption to insoluble wall components. In the present study, we examined a commercial preparation of pectin and seven other soluble-fiber polysaccharides with diverse structures for their effects on the distribution of DNP. Many of these are used as emulsifiers and stabilizers in the food industry. They all maintained DNP in aqueous solution and decreased its ads...Continue Reading

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Citations

Nov 1, 1993·Mutation Research·P J Harris, L R Ferguson
Nov 1, 1993·Mutation Research·L R Ferguson
Jan 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T L TorzsasA V Rao
Dec 1, 1993·Mutation Research·A TurturroR W Hart
Mar 24, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·P KestellL R Ferguson
Sep 1, 1995·Journal of the American Dietetic Association·R H CoxE Smith
Feb 7, 2001·Mutation Research·L R Ferguson, P J Harris
Feb 2, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C A TaG Poirier
May 26, 1998·Mutation Research·P J HarrisL R Ferguson
May 20, 2006·Journal of Epidemiology·Kenji WakaiKazuo Tajima
Mar 8, 1996·Chemico-biological Interactions·P J HarrisL R Ferguson
May 13, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Viola AdamssonUlf Risérus
Jan 1, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·K S PetersenJ B Keogh

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