The effects of somatostatin, its fragments and an analog on electroconvulsive shock-induced amnesia in rats

Neuropeptides
L VécseiG Telegdy

Abstract

In the present study the effects of intracerebroventricularly [icv] administered somatostatin [linear and cyclic], somatostatin3-6, somatostatin7-10 and des AA1,2,4,5,12,13 [D-Trp8] somatostatin [ODT8-SS] were investigated on electroconvulsive shock [ECS]-induced retrograde amnesia in rats. The ECS significantly decreased the foot shock-induced avoidance latency, and thus caused retrograde amnesia. Somatostatin [linear and cyclic] in a dose of 0.6 nM had no action on the ECS-induced retrograde amnesia, while in doses of 3 nM and [cyclic only] 6 nM it significantly prevented it. Somatostatin3-6, somatostatin7-10 and ODT8-SS in doses of 0.6, 3 and 6 nM had no effect on the ECS-induced amnesia. These results indicate that the whole sequence of the original somatostatin molecule is needed to block the ECS-caused retrograde amnesia.

References

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Citations

Oct 1, 1991·Annals of Neurology·M M MouradianT N Chase
Jul 1, 1995·Archives of Gerontology and Geriatrics·L Vécsei, P Klivényi
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·L Merlini, M Pinza
Apr 9, 2008·Learning & Memory·Christian KlugeHans-Christian Pape
Mar 31, 2006·Journal of Neurophysiology·Toshihiko Momiyama, Laszlo Zaborszky
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Related Concepts

Amnestic State
Retrograde Memory Loss
Metazoa
Electroconvulsive Shock
Somatofalk
Structure-Activity Relationship
Rats, Laboratory

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