PMID: 1197790Oct 1, 1975Paper

The effects of some natural prostaglandins on isolated human circular bronchial muscle

Prostaglandins
P J Gardiner

Abstract

PGE1 relaxed isolated human circular bronchial muscle over a wide concentration range as did isoprenaline. Surprisingly isoprenaline was more potent than PGE1. PGF2alpha weakly contracted this muscle preparation whereas histamine was more potent. PGE2, however, produced paradoxical results, relaxing some tissues and contracting others, always in a concentration-related manner irrespective of tissue tone. In preparations that contracted to PGE2, tachyphylaxis induced to PGF2alpha also applied to PGE2, but did not affect PGE1 relaxations of histamine contractions. These findings suggest that pge2 can stimulate either PGF2alpha or PGE1 receptors of isolated human bronchial muscle.

References

Jul 1, 1971·Acta Physiologica Scandinavica·P HedqvistA A Mathé

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Citations

Jan 1, 1986·Lung·S P Hanley
Dec 1, 1978·Prostaglandins·P Grella, P Zanor
Feb 1, 1978·Prostaglandins·P J GardinerH O Collier
Jun 1, 1980·Prostaglandins·P J Gardiner, H O Collier
Mar 1, 1981·Prostaglandins·J E BirnbaumL VanHumbeeck
Mar 1, 1985·Prostaglandins·E NizankowskaA Szczeklik
Jan 1, 1989·Pharmacology & Therapeutics·P J Gardiner
Feb 26, 2000·European Journal of Pharmacology·M Richter, P Sirois
Aug 29, 2003·Medical Hypotheses·K UchidaS Takagi
Dec 12, 2001·British Journal of Pharmacology·L WalchX Norel
Mar 1, 1981·Clinical and Experimental Pharmacology & Physiology·B R Creese, M A Denborough
Aug 1, 1995·Thorax·A J Knox, A E Tattersfield
Aug 1, 1987·Journal of Cardiothoracic Anesthesia·W J GreeleyJ G Reves
May 13, 2015·The Journal of Allergy and Clinical Immunology·Jesper SäfholmMikael Adner
Nov 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·I RamisA A Vidal
Dec 20, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Nowshin N Rumzhum, Alaina J Ammit
Dec 1, 1986·Journal of Cardiac Surgery·W J GreeleyW D Watkins
Nov 3, 1977·Nature·S A SaeedH O Collier
Mar 1, 1980·British Journal of Pharmacology·R A Coleman, I Kennedy
Jul 1, 1980·British Journal of Pharmacology·C BrinkJ Orehek

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