The effects of spaceflight and fracture healing on distant skeletal sites

Scientific Reports
Ushashi C DadwalMelissa A Kacena

Abstract

Spaceflight results in reduced mechanical loading of the skeleton, which leads to dramatic bone loss. Low bone mass is associated with increased fracture risk, and this combination may compromise future, long-term, spaceflight missions. Here, we examined the systemic effects of spaceflight and fracture surgery/healing on several non-injured bones within the axial and appendicular skeleton. Forty C57BL/6, male mice were randomized into the following groups: (1) Sham surgery mice housed on the earth (Ground + Sham); (2) Femoral segmental bone defect surgery mice housed on the earth (Ground + Surgery); (3) Sham surgery mice housed in spaceflight (Flight + Sham); and (4) Femoral segmental bone defect surgery mice housed in spaceflight (Flight + Surgery). Mice were 9 weeks old at the time of launch and were euthanized approximately 4 weeks after launch. Micro-computed tomography (μCT) was used to evaluate standard bone parameters in the tibia, humerus, sternebra, vertebrae, ribs, calvarium, mandible, and incisor. One intriguing finding was that both spaceflight and surgery resulted in virtually identical losses in tibial trabecular bone volume fraction, BV/TV (24-28% reduction). Another important finding was that surgery markedly ch...Continue Reading

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Citations

Jan 4, 2020·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Yasir ArfatCharles H Hocart
Aug 28, 2020·Frontiers in Physiology·Neeki Ashari, Alan R Hargens
Jan 4, 2020·Current Osteoporosis Reports·Jennifer C CoulombeVirginia L Ferguson
Jun 9, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nabarun ChakrabortyRasha Hammamieh
Feb 14, 2021·Journal of Biomechanics·Neeki AshariAlan R Hargens
Mar 14, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ushashi C DadwalMelissa A Kacena
May 1, 2021·International Journal of Molecular Sciences·Shirley GenahLucia Morbidelli
Jun 3, 2021·NPJ Microgravity·Jingyan FuSvetlana V Komarova
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Konstantinos AdamopoulosGeorge I Lambrou
Jul 2, 2021·Computational and Structural Biotechnology Journal·Nabarun ChakrabortyMelissa A Kacena

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