PMID: 602926Jan 1, 1977Paper

The effects of splenectomy and glucocorticoids on survival and hepatic uptake of damaged red cells in the mouse

American Journal of Hematology
D J GanickM R Klemperer

Abstract

We have studied the effects of splenectomy and glucocorticoids on the survival and sequestration of Heinz body-containing red blood cells (RBC-HZB). Mice were injected with phenylhydrazine damaged 51Cr labeled isologous red blood cells (RBCs). The spleen removed 36% and the liver 19% of the injected dose after 120 hrs. Red cell survival (T 1/2) fell from 180 hrs for undamaged red cells to 16 hrs for RBC-HZB. Splenectomy resulted in an increase in hepatic uptake of damaged RBCs (36% of the injected dose) and a modest improvement in red cell survival (T 1/2 54 hrs). Treatment of non-splenectomized mice with glucocorticoids reduced the splenic uptake to 16% and the hepatic uptake to 14% of the injected dose. The reduction of splenic upatke was associated with a decrease in splenic mass rather than a decrease in uptake per unit weight of splenic tissue, while reduction in hepatic uptake was associated with both a decrease in hepatic mass and uptake per unit weight. A marked decrease was observed in hepatic uptake and in phagocytosis by Kupffer cells in glucocorticoid-treated splenectomized mice. These data suggest that increased hepatic uptake may decrease the effectiveness of splenectomy in RBC-HZB hemolytic anemia and that glucoc...Continue Reading

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Citations

Mar 15, 2011·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·M Desmarets, F Noizat-Pirenne
Jan 27, 2015·Annual Review of Pathology·James C Zimring, Steven L Spitalnik
Oct 18, 2006·European Journal of Haematology·Anna Lisa GiulianiGilberto Berti
Jan 1, 1984·Nutrition and Cancer·V Herbert
Jun 3, 2008·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Anders Hedenström
Aug 16, 2005·The Journal of Pharmacology and Experimental Therapeutics·Zachary S BowmanDavid C McMillan
Jul 1, 1988·European Journal of Haematology·L D De HaanG E Staal

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