PMID: 6401817Jan 1, 1983Paper

The effects of splenectomy and splenic implantation on alveolar macrophage function

The Journal of Trauma
H ShennibD S Mulder

Abstract

The effect of splenectomy on the ability of alveolar macrophages of young and adult rats to phagocytize Pneumococci, Types 3 and 14, and Pseudomonas aeruginosa was studied. Young animals showed a significant (15%) decrease in the phagocytosis of pneumococci type 14, 4 weeks after splenectomy. This depression increased to 30% in 6 weeks' time. Such depression was also noted when young splenectomized rat alveolar macrophages were challenged with Pseudomonas aeruginosa but not with type 3 pneumococci 6 weeks postsplenectomy. Three months following splenectomy in young animals, the rats were grown and they seemed to regain their normal phagocytic activity against pneumococci type 14. Adult rats also showed no alteration in their phagocytic activity against type 3 pneumococci. Autoimplantation of the spleen had a protective effect on the phagocytosis of type 14 pneumococci, and a nonsignificant effect on that of type 3. The present study postulates a modulatory role of the spleen on alveolar macrophage function. Splenectomy may cause the impairment of local lower respiratory immune function, making lungs vulnerable to specific bacterial invasion. Such splenic modulatory effect on alveolar macrophage phagocytic function seems to be a...Continue Reading

Citations

Apr 1, 1985·World Journal of Surgery·R J Touloukian
Apr 1, 1985·World Journal of Surgery·C J Stolar, R P Altman
Oct 29, 2002·The American Journal of Medicine·Wang YongxiangWu Tao
May 1, 1985·Annals of Surgery·D V FelicianoG L Jordan
Feb 1, 1991·Annals of Surgery·C E Lucas
Apr 11, 2015·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Alcino Lázaro da Silva
May 1, 1987·The British Journal of Surgery·A Di CataldoG Rodolico
Feb 18, 2003·Acta chirurgica Iugoslavica·S KnezevićM Popović
Sep 5, 2012·Clinical and Experimental Immunology·R G MarquesM Bernardo-Filho
Oct 10, 2003·Arquivos De Gastroenterologia·Ruy Garcia Marques, Andy Petroianu

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