The effects of SRS-A and histamine antagonists on antigen-induced contraction of guinea pig trachea

European Journal of Pharmacology
J F Burka, N A Paterson

Abstract

Spirally cut tracheae from actively sensitized guinea pigs were challenged with antigen in the presence and absence of indomethacin. In the absence of indomethacin, the SRS-A antagonist FPL55712, added 30 min before challenge had no effect on antigen-induced contraction (ATC) when added in concentrations less than or equal to 1.7 X 10(-6) M. However with the highest concentration employed (5.2 X 10(-6) M) the duration of ATC was reduced by 45%. Furthermore the enhancement by indomethacin of the peak height of ATC was reduced even by lower (5.2 X 10(-7) M) concentrations of FPL55712. The inhibition of FPL55712 was time-dependent, suggesting that its action was not confined to competitive receptor antagonism. Hence, although our previous data indicate that a lipoxygenase product is involved in ATC, the current findings suggest that lipoxygenase products in addition to SRS-A contribute to the response. THe H1-antagonists mepyramine, chlorpheniramine and diphenhydramine inhibited ATC only in the first minute, and the peak height was reduced only by diphenhydramine. The H2-antagonist cimetidine had no effect on ATC. These data suggest that the contribution of histamine to ATC is small, confined to the first minute following antigen ...Continue Reading

References

Jan 1, 1978·Biochemical Pharmacology·M Chasin, C Scott
Nov 17, 1977·Nature·G K Adams, L M Lichtenstein
May 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·W J KoopmanK F Austen
Oct 17, 1973·Nature: New Biology·J AugsteinM L Tattersall
May 1, 1974·The Journal of Allergy and Clinical Immunology·P D JoinerF Hahn
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·L OrningB Samuelsson
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R A LewisE J Corey
Jun 1, 1980·Prostaglandins·P J Gardiner, H O COLLIER
Apr 1, 1980·Prostaglandins·J F Burka, N A Paterson
Jun 1, 1980·British Journal of Pharmacology·J J Adcock, L G Garland
Aug 1, 1964·British Journal of Pharmacology and Chemotherapy·P A BERRY, H O COLLIER
Jun 1, 1965·The Journal of Pharmacy and Pharmacology·J W CONSTANTINE

Citations

Dec 1, 1985·Agents and Actions·P O Ogunbiyi, P Eyre
Jul 23, 1987·European Journal of Pharmacology·B J UndemG K Adams
Jun 8, 1989·European Journal of Pharmacology·D G Redkar-Brown, D Aharony
Apr 6, 1993·European Journal of Pharmacology·R J HeaslipB M Weichman
Jan 1, 1988·International Journal of Immunopharmacology·A M Genaro, E S Borda
Oct 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·K DobashiT Nakazawa
Jun 1, 1984·Journal of Veterinary Pharmacology and Therapeutics·P O Ogunbiyi, P Eyre
Mar 1, 1989·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·E RagazziG Fassina
Jul 1, 1985·Pediatric Pulmonology·M Souhrada, J F Souhrada

Related Concepts

FPL 55712
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Metazoa
Antigens
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