The effects of steel mutation on testicular germ cell differentiation

Journal of Cellular Physiology
Y NishimuneY Kitamura

Abstract

The effects of artificial cryptorchidism and its surgical reversal on spermatogenesis were examined in germ cell mutant, S1/+ and wild type, +/+, mice. In cryptorchid testes no difference was found between S1/+ and +/+ mice in the number of undifferentiated type A spermatogonia. The activity of type A spermatogonia in mutant mice appeared normal as judged by its mitotic cell number and DNA synthesis. The surgical reversal of cryptorchidism resulted in regenerative differentiation of mature germ cells in both types of mice, but the pattern of cellular differentiation in the mutant testes was completely different from that of the wild type testes. At two steps of cellular differentiation, intermediate or type B spermatogonia and spermatid, the numbers of cells were much smaller in the S1/+ testes than those in the +/+ testes. The steel gene was therefore suggested to exert its effects on the differentiation of type A spermatogonia to intermediate or type B spermatogonia, on meiotic division and/or the survival rate of these cells, but not on the undifferentiated type A spermatogonia or stem cells.

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Citations

May 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·B Motro, A Bernstein
Nov 1, 1995·Molecular Reproduction and Development·A I PackerR F Bachvarova
Mar 1, 1988·Developmental Biology·H KurodaY Kitamura
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S A KellerM H Meisler
Apr 1, 1994·International Journal of Andrology·E Rajpert-De Meyts, N E Skakkebaek
Oct 15, 1982·Biochemical and Biophysical Research Communications·T HanejiY Nishimune
Jan 1, 1984·Journal of Cellular Physiology·Y NishimuneY Kitamura
Feb 1, 1996·The Journal of Pathology·E Rajpert-De MeytsN E Skakkebaek
Jan 1, 1985·Archives of Andrology·Y NishimuneY Kitamura

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