The effects of strength training and raloxifene on bone health in aging ovariectomized rats

Bone
Camila Tami Stringhetta-GarciaRita Cássia Menegati Dornelles

Abstract

The aim of this study was to investigate the effects of strength training (ST) and raloxifene (Ral), alone or in combination, on the prevention of bone loss in an aging estrogen-deficient rat model. Aging Wistar female rats were ovariectomized at 14months and allocated to four groups: (1) non-trained and treated with vehicle, NT-Veh; (2) strength training and treated with vehicle, ST-Veh; (3) non-trained and treated with raloxifene, NT-Ral; and (4) strength training and treated with raloxifene, ST-Ral. ST was performed on a ladder three times per week and Ral was administered daily by gavage (1mg/kg/day), both for 120days. Areal bone mineral density (aBMD), strength, microarchitecture, and biomarkers (osteocalcin, OCN; osteoprotegerin, OPG; and tartrate-resistant acid phosphatase, TRAP) were assessed. Immunohistochemistry was performed for runt-related transcription factor 2 (RUNX2), osterix (OSX), OCN, OPG, TRAP, and receptor activator of nuclear factor kappa-B ligand (RANKL). The rats that performed ST (ST-Veh) or were treated with Ral (NT-Ral) showed significant improvements in aBMD (p=0.001 and 0.004), bone strength (p=0.001), and bone microarchitecture, such as BV/TV (%) (p=0.001), BS/TV (mm(2)/mm(3)) (p=0.023 and 0.002), ...Continue Reading

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Citations

Dec 3, 2016·Lasers in Medical Science·Samuel Rodrigues Lourenço MoraisRita Cássia Menegati Dornelles
Feb 18, 2017·Scientific Reports·Monique Patricio SingulaniRita Cássia Menegati Dornelles
Oct 17, 2017·Clinical Oral Investigations·Matheus da Silva BrasilinoAntonio Hernandes Chaves-Neto
Nov 2, 2017·Scientific Reports·Camila Tami Stringhetta-GarciaRita Cássia Menegati Dornelles
Oct 17, 2017·Journal of Exercise Nutrition & Biochemistry·Yun-Seok KangJeong-Seok Kim
Oct 7, 2019·Journal of Bone and Mineral Metabolism·Yusuke YuasaYoichi Shimada
May 15, 2020·Scientific Reports·Fernanda FernandesRita Cássia Menegati Dornelles
Jan 2, 2021·Frontiers in Cell and Developmental Biology·Qian LiuGuangwei Wang
Feb 15, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nur-Vaizura MohamadKok-Yong Chin
Feb 26, 2020·Bone·Melise Jacon Peres-UenoRita Cassia Menegati Dornelles
Oct 22, 2018·Life Sciences·Rodrigo Mello GomesSolange Marta Franzói de Moraes
May 4, 2021·Biological Trace Element Research·Rui LiZilong Sun

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