Sep 29, 2005

The effects of stress on wound healing in male tree lizards (Urosaurus ornatus)

General and Comparative Endocrinology
Susannah S FrenchMichael C Moore

Abstract

Exposure to stress can affect an organism's partitioning of resources among immune function and other organismal functions. However, measuring immune function is often difficult. Recent studies show that the rate of cutaneous wound healing in laboratory rodents is a simple, integrated measure of stress-sensitive immune function. We investigated the use of this technique in tree lizards to test the hypotheses (1) that stress compromises wound healing and (2) that this effect is at least partially mediated by corticosterone. Laboratory-housed male tree lizards randomly assigned to the experimental and control treatment groups received a 3.5 mm cutaneous biopsy on the dorsal surface of the pelvis. Experimental group males were restrained in cloth bags for 60 min every day for 21 days during the healing profile, whereas control males were left in their cages. Wound sizes were measured every other day by image analysis. Control animals healed faster than stressed animals. The difference in wound surface area between the groups was most pronounced early in the healing profile. Stressed animals also had higher corticosterone levels and corticosterone was negatively correlated with healing rate in the stressed animals. These observatio...Continue Reading

  • References17
  • Citations49

References

  • References17
  • Citations49

Citations

Mentioned in this Paper

Neuro-Oncological Ventral Antigen 2
Corticosterone Assay
Biochemical Pathway
Malignant Neoplasm of Pelvis
Immune System
Testosterone Measurement
Biological Adaptation to Stress
Urosaurus ornatus
Glucocorticoid inhalants for obstructive airway disease
Acclimatization

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