The effects of substituted benzamides on frog rectus abdominis

European Journal of Pharmacology
J Fontaine, J Reuse

Abstract

The substituted benzamides metoclopramide, bromopride, tiapride and sulpiride (10(-5) and 10(-4) M) significantly increased the sensitivity of frog rectus abdominis muscle to exogenous acetylcholine but not to carbachol. This supersensitivity could be correlated with the anticholinesterase activity of these drugs measured in homogenates from frog skeletal muscle. Sultopride, like procainamide, has only inhibitory effects on the responses of the rectus abdominis to acetylcholine and has no anticholinesterase activity in this preparation.

References

Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE

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Citations

Jan 22, 1985·European Journal of Pharmacology·M W LobbezooJ M Zwagemakers
Jul 23, 2005·International Journal of Toxicology·G A PetroianuM Y Hasan
Oct 29, 2010·Journal of Applied Toxicology : JAT·Dietrich E LorkeGeorg A Petroianu
Sep 30, 2005·Journal of Applied Toxicology : JAT·G A PetroianuA Schmitt
Jul 22, 2018·Journal of Applied Toxicology : JAT·Dietrich E Lorke, Georg A Petroianu

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