The effects of surface topography of nanostructure arrays on cell adhesion

Physical Chemistry Chemical Physics : PCCP
Jing ZhouTongsheng Chen

Abstract

Nanostructure arrays have drawn much attention and are promising as new biomaterials in the field of biomedicine. In recent years, numerous experimental studies on the cell behavior of nanostructured arrays (NSs) have been published, describing a wide variety of experimental results. But there are only a few theoretical analyses that elucidate the mechanisms of interactions between cells and nanostructures. Here we present a quantitative thermodynamic model to elucidate the effects of surface topography of nanostructure arrays on cell adhesion. Based on the established model, we studied the equilibrium state of cell adhesion by analyzing the change in free energy during the adhesion process. Theoretical results showed that cell adhesion mode is actually determined by the balance between adhesion energy and deformation energy of the cell membrane. According to the calculated results, a phase diagram of the cell adhesion has been constructed, which can clarify the interrelated effects of the radius and surface distribution density of nanopillars. We can identify the relation between the surface topography of nanostructure arrays and the cell adhesion mode from the phase.

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Citations

Nov 24, 2018·Physical Chemistry Chemical Physics : PCCP·Shriram JanghelaNamburi Eswara Prasad
Jul 25, 2019·Critical Reviews in Biotechnology·Guangshun YiYugen Zhang
Jan 17, 2020·Advanced Materials·Stuart G HigginsMolly M Stevens
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Dec 18, 2020·Physical Review. E·Jing ZouXinlei Li
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Jul 13, 2021·ACS Applied Materials & Interfaces·Mahdiyeh Nouri-GoushkiAmir A Zadpoor
Oct 10, 2020·The Journal of Physical Chemistry Letters·Daniil V KladkoVladimir V Vinogradov

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