The effects of surgery on the activity of neutrophil granule proteins

British Journal of Haematology
J M DaviesJ Fletcher

Abstract

Activities of the neutrophil granule-associated proteins beta-glucuronidase, lysozyme and vitamin B12 binding protein were measured, serially, in the cells and serum of 10 patients undergoing total abdominal hysterectomy. The neutrophil leucocytosis which followed total abdominal hysterectomy was accompanied by a fall in the intraneutrophilic activities of all three granule-associated proteins. Intraneutrophilic lysozyme activity and intraneutrophilic vitamin B12 binding capacity were maximally reduced within 4 h of surgery and fell to 62 +/- 13% (mean +/- SEM) and 63 +/- 9% of their preoperative levels, respectively. This contrasted with the activity of intraneutrophilic beta-glucuronidase which was not maximally reduced until 24 h post-surgery when a fall to 80 +/- 6% of the preoperative level was observed. By the fifth postoperative day activities of the three intraneutrophilic granule proteins were increasing and approaching those observed preoperatively. Serum lysozyme and plasma unsaturated vitamin B12 binding capacity (UBBC) rose steadily following surgery and were significantly elevated by the fifth postoperative day. It is suggested that activation and in vivo degranulation of circulating neutrophils may be responsible...Continue Reading

References

Apr 1, 1978·Anaesthesia·B Walton
Aug 1, 1978·British Journal of Haematology·R M Bennett, T Kokocinski
Nov 22, 1976·Biochemical and Biophysical Research Communications·J D SimonM M Albala
Aug 1, 1977·Biochemical Medicine·H J KlassT J Peters
Jan 1, 1975·British Journal of Haematology·D F Bainton
Sep 1, 1973·The Tohoku Journal of Experimental Medicine·S KomuraK Fujimura
May 1, 1974·The Journal of Experimental Medicine·S GordonZ A Cohn
Dec 1, 1971·British Journal of Haematology·D CatovskyL Szur
Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·C E Mogensen
Feb 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R S BriggsS C Finch
Mar 1, 1967·Clinica Chimica Acta; International Journal of Clinical Chemistry·W H FishmanS Green
Apr 1, 1981·Infection and Immunity·H El-Maallem, J Fletcher
May 1, 1981·The Journal of Clinical Investigation·A A VoetmanD Roos
Sep 1, 1958·American Journal of Clinical Pathology·P G CABAUD, F WROBLEWSKI

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Citations

Apr 1, 1992·Acta Anaesthesiologica Scandinavica·M Salo
May 30, 1998·Acta Anaesthesiologica Scandinavica·A HellerT Koch
Feb 1, 1986·Acta Anaesthesiologica Scandinavica·J PerttiläM Salo
Nov 1, 1991·Scandinavian Journal of Clinical and Laboratory Investigation·H Berner BerntzenP Mowinckel
Jul 1, 1988·The British Journal of Surgery·J UtohY Miyauchi
Jun 1, 1992·The British Journal of Surgery·R A LordJ L Francis
Oct 1, 1996·European Journal of Clinical Investigation·T KochH Neuhof
May 1, 1989·Journal of Gastroenterology and Hepatology·G H De GrootO T Terpstra
Dec 1, 1995·Current Problems in Surgery·C C Baker, M D Huynh

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