The effects of systemic, topical, and intralesional steroid treatments on apoptosis level of nasal polyps

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Burak KapucuUfuk Berber

Abstract

The purpose of this study was to compare the apoptotic responses to systemic, topical, and intrapolyp injection of glucocorticoid with no treatment in nasal polyps. Prospective, randomized controlled study. Tertiary training hospital. The study was performed on 48 patients with nasal polyposis in the Department of Otorhinolaryngology between 2008 and 2009. Patients were assigned to 1 of 4 groups of 12 patients. Group A was treated with oral methylprednisolone 1 mg/kg/d, and the dose was tapered gradually. Group B received 0.3 mL triamcinolone acetonide (40 mg/mL), which was injected into polyp tissue. Group C was treated with topical 55 µg triamcinolone acetonide 2 times daily for 1 month. Group D received no medication. Samples were collected endoscopically after the seventh day for groups A and B, the first month for group C, and the first visit for group D. Apoptotic indexes were determined using the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling method. Statistically significant differences in apoptotic index were found between each steroid-medicated group and the control group (P (D-A) = .0001; P (D-B) = .003; P (D-C) = .026) and between groups A and C (P (A-C) = .012). Group B did not differ signifi...Continue Reading

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Citations

Dec 25, 2012·Current Opinion in Otolaryngology & Head and Neck Surgery·John S SchneiderJames A Duncavage
Dec 17, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Cheng ZhongXueyuan Zhang
Aug 28, 2016·American Journal of Otolaryngology·Dong Sik ChangChin Saeng Cho
Apr 27, 2016·The Cochrane Database of Systematic Reviews·Karen HeadAnne G M Schilder
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Mar 22, 2018·Frontiers in Molecular Neuroscience·Umberto CrisafulliIsaias Glezer

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Software Mentioned

Statistical Package for Social Sciences ( SPSS

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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