The effects of temperature and salinity on 17-α-ethynylestradiol uptake and its relationship to oxygen consumption in the model euryhaline teleost (Fundulus heteroclitus)

Aquatic Toxicology
Tamzin A BlewettChris M Wood

Abstract

The synthetic estrogen 17-α-ethynylestradiol (EE2), a component of birth control and hormone replacement therapy, is discharged into the environment via wastewater treatment plant (WWTP) effluents. The present study employed radiolabeled EE2 to examine impacts of temperature and salinity on EE2 uptake in male killifish (Fundulus heteroclitus). Fish were exposed to a nominal concentration of 100ng/L EE2 for 2h. The rate of EE2 uptake was constant over the 2h period. Oxygen consumption rates (MO(2)), whole body uptake rates, and tissue-specific EE2 distribution were determined. In killifish acclimated to 18°C at 16ppt (50% sea water), MO(2) and EE2 uptake were both lower after 24h exposure to 10°C and 4°C, and increased after 24h exposure to 26°C. Transfer to fresh water (FW) for 24h lowered EE2 uptake rate, and long-term acclimation to fresh water reduced it by 70%. Both long-term acclimation to 100% sea water (32ppt) and a 24h transfer to 100% sea water also reduced EE2 uptake rate by 50% relative to 16ppt. Tissue-specific accumulation of EE2 was highest (40-60% of the total) in the liver plus gall bladder across all exposures, and the vast majority of this was in the bile at 2h, regardless of temperature or salinity. The carca...Continue Reading

References

Jan 1, 1985·Comparative Biochemistry and Physiology. A, Comparative Physiology·E W Taylor, D J Barrett
Nov 1, 1971·Bulletin of Environmental Contamination and Toxicology·P G Murphy, J V Murphy
Sep 1, 1996·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G T SmithG S Prins
Jan 1, 1997·Annual Review of Physiology·S F Perry
Aug 26, 1998·Critical Reviews in Toxicology·C R TylerJ P Sumpter
Mar 20, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·S F Perry
Nov 1, 2001·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·M Grosell, C M Wood
Apr 12, 2003·Environmental Science & Technology·Karen L ThorpeCharles R Tyler
Jan 20, 2004·Biochimica Et Biophysica Acta·Chris M Wood, Pierre Laurent
Aug 4, 2004·Respiratory Physiology & Neurobiology·H O PörtnerC Bock
Jul 3, 2007·The Journal of Experimental Biology·Göran E Nilsson
Apr 2, 2008·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Chris M Wood, Martin Grosell
May 17, 2008·Endocrinology·Solange Miguel-Queralt, Geoffrey L Hammond
Jul 16, 2008·The Journal of Experimental Biology·Graham R ScottChris M Wood
Feb 24, 2010·Journal of Environmental Quality·Charles W Walker, John E Watson

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Citations

Jan 30, 2014·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Tamzin A BlewettChris M Wood
Dec 30, 2014·Archives of Environmental Contamination and Toxicology·Tamzin A Blewett, Chris M Wood
Apr 19, 2016·Environmental Toxicology and Chemistry·Thijs BoskerDeborah L MacLatchy
Nov 21, 2015·Environmental Toxicology and Chemistry·Bowen DuBryan W Brooks
Dec 6, 2018·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Alex M ZimmerChris M Wood
Feb 4, 2021·Scientific Reports·Caren L S VilelaRaquel S Peixoto
Sep 23, 2021·Ecological Applications : a Publication of the Ecological Society of America·Erin S McCallumTomas Brodin

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