The effects of tempol, 3-aminobenzamide and nitric oxide synthase inhibitors on acoustic injury of the mouse cochlea

Hearing Research
Hidekazu MurashitaAkira Hara

Abstract

Oxygen free radicals have been implicated in the pathogenesis of acoustic injury of the cochlea. The purpose of this study was to evaluate the effects of tempol (a superoxide anion scavenger), 3-aminobenzamide (a poly (ADP-ribose) synthetase (PARS) inhibitor), N-nitro-l-arginine (a non-selective nitric oxide synthase (NOS) inhibitor), 7-nitroindazole (a selective neuronal NOS inhibitor) and aminoguanidine (a selective inducible NOS inhibitor) on acoustic injury. Mice were exposed to a 4 kHz pure tone of 110-128 dB SPL for 4h. Tempol, 3-aminobenzamide or N-nitro-l-arginine was intraperitoneally administered immediately before the onset of acoustic overexposure, while 7-nitroindazole or aminoguanidine was intraperitoneally administered every 12h starting immediately before the onset of acoustic overexposure. The threshold shift of the auditory brainstem response (ABR) and hair cell loss were then evaluated one and two weeks after acoustic overexposure. Tempol and 3-aminobenzamide significantly protected the cochlea against acoustic injury, whereas the NOS inhibitors did not exert any protective effect. These findings suggest that reactive oxygen species and PARS are involved in acoustic injury of the cochlea. However, further stu...Continue Reading

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Citations

Apr 29, 2009·The Tohoku Journal of Experimental Medicine·Isao UemaetomariAkira Hara
Oct 25, 2011·Biochemical and Biophysical Research Communications·Tomofumi HoshinoAkira Hara
Sep 16, 2008·Hearing Research·Kevin K Ohlemiller
Jul 1, 2008·Hearing Research·Guang-Di ChenDonald Henderson
Nov 17, 2011·Hearing Research·Nadia PilatiMartine Hamann
Mar 14, 2007·Neuroscience Letters·Hidekazu MurashitaAkira Hara
Jun 3, 2011·Acta Oto-laryngologica·Keiji TabuchiAkira Hara
Jun 18, 2016·Acta Oto-laryngologica·Hiroshi NonoyamaHiromi Ueda
Nov 22, 2016·International Journal of Molecular Sciences·Cha Kyung YounSung Il Cho
Oct 27, 2007·Free Radical Research·Xiaorui ShiAlfred Nuttall
Apr 27, 2010·Pharmaceuticals·Tomofumi HoshinoAkira Hara
Apr 21, 2018·Journal of Neurochemistry·Shigefumi MoriokaTakehiko Ueyama
Jun 30, 2018·Physiological Genomics·Janet L Fitzakerley, George J Trachte
May 27, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Min XiongGuangjuan Zheng
Oct 22, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Mahmut OgurluEngin Dursun
Aug 23, 2008·The Tohoku Journal of Experimental Medicine·Tomofumi HoshinoAkira Hara
Apr 8, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Seyit Mehmet CeylanMustafa Emre Gulbagci

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