The effects of testosterone and oestrogen on gonadectomised and intact male rat anterior pituitary mitotic and apoptotic activity

The Journal of Endocrinology
L A Nolan, A Levy

Abstract

We have used a direct, non-immunochemical and highly accurate method to quantify the effects of testosterone and oestrogen on mitotic and apoptotic activity in the young, male rat anterior pituitary in vivo. Surgical gonadectomy resulted in a 3-fold increase in mitotic activity by the fourth post-operative day, which returned gradually to levels seen in intact animals over the subsequent 3-4 weeks. Both a single dose of Sustanon, a mixture of long-acting testosterone esters in arachis oil, and the same dose divided over 7 days (starting 6 days after gonadectomy), initially suppressed mitotic activity to levels seen in intact animals, but was associated after 48-96 h with a wave of increased mitotic activity. The latter was blocked by co-administration of Sustanon with the non-steroidal aromatase inhibitor letrozole and was not seen when the non-aromatisable androgen dihydrotestosterone was substituted for Sustanon. Oestrogen alone in gonadectomised and intact rats produced a marked increase in mitosis as expected. With the exception of a transient increase in response to a single high-dose injection of Sustanon in gonadectomised animals, apoptotic activity was unaffected by all of the above. This study suggests that pituitary m...Continue Reading

Citations

Jul 25, 2008·Head & Face Medicine·Jens WeingärtnerPeter Proff
Jul 21, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Takashi NakakuraShigeyasu Tanaka
Sep 3, 2013·Molecular and Cellular Endocrinology·Hugo Vankelecom, Jianghai Chen
Jul 3, 2009·Psychoneuroendocrinology·Jiska S PeperHilleke E Hulshoff Pol
Jun 16, 2009·Molecular and Cellular Endocrinology·Caroline MazurikaMoshe Gavish
May 11, 2013·General and Comparative Endocrinology·Matan Golan, Berta Levavi-Sivan
Sep 13, 2014·Journal of Affective Disorders·Ian A ClarkGuy M Goodwin
Jan 23, 2009·American Journal of Physiology. Endocrinology and Metabolism·S ZárateA Seilicovich
Mar 24, 2009·Journal of Neuroendocrinology·L A Nolan, A Levy
Dec 12, 2020·Archives of Oral Biology·Natália Amanda GomesJoão Paulo Steffens
Dec 4, 2019·General and Comparative Endocrinology·Romain FontaineFinn-Arne Weltzien
Jan 30, 2008·Endocrinology and Metabolism Clinics of North America·Andy Levy

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