PMID: 240472Jul 1, 1975Paper

The effects of tetraphenylboron on spontaneous transmitter release at the frog neuromuscular junction

British Journal of Pharmacology
I G Marshall, R L Parsons

Abstract

1 The effects of tetraphenylboron (TPB) on spontaneous transmitter release were studied in the frog sartorius muscle preparation. 2 TPB (0.001-1 mM) produced a time-dependent increase in miniature endplate potential (m.e.p.p.) activity that was not sustained. TPB (0.1 mM) produced similar effects on m.e.p.p. frequency in normal Ringer solutions, in the absence of Ca2+ or Cl- and in the presence of excess Ca2+ and of tetrodotoxin. The effect of TPB (0.01 mM) was reduced but not abolished in the absence of Ca2+. 3 As m.e.p.p. frequency fell from its peak level in TPB (0.04 mM) m.e.p.p. amplitude was reduced. The reduction of m.e.p.p. amplitude was not prevented by choline (30-300 muM). 4 When m.e.p.p. activity fell below the noise level in the presence of TPB (0.1 mM), lanthanum (0.5 mM) was ineffective in promoting measurable m.e.p.p. activity. 5 The effects of TPB were slowly reversible by washing. 6 The results indicate that TPB acts to reduce the nerve terminal stores of acetylcholine, probably by a combination of rapid release and concomitant inhibition of transmitter storage.

References

Jul 1, 1975·British Journal of Pharmacology·I G Marshall, R L Parsons
Jul 1, 1975·British Journal of Pharmacology·I G Marshall, R L Parsons
Nov 1, 1967·Archives of Biochemistry and Biophysics·K Utsumi, L Packer
Nov 1, 1968·The Journal of Physiology·Z L BliochV A Nenashev
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·R Rahamimoff, E Alnaes
Jul 1, 1974·The Journal of Physiology·D A BoroffR A Steinhardt
Jan 1, 1971·Journal of Neurobiology·W A DeBassioR L Parsons
May 20, 1974·Biochemical and Biophysical Research Communications·G M WagnerR B Kelly
Sep 17, 1968·Biochimica Et Biophysica Acta·E A Liberman, V P Topaly
Apr 1, 1965·The Journal of Physiology·D ELMQVIST, D M QUASTEL

Citations

Jan 1, 1991·Progress in Neurobiology·W Van der Kloot
Dec 1, 1994·General Pharmacology·A R DehpourM Azizabadi-Farahani
Jan 1, 1977·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·A L Harvey, I G Marshall
Jan 1, 1979·Neuroscience·J M FarleyT Narahashi
Jun 1, 1977·British Journal of Pharmacology·H L Haas, R W Ryall
Jan 1, 1986·Pflügers Archiv : European journal of physiology·W Van der Kloot
Feb 1, 1987·Toxicology and Applied Pharmacology·P C Levesque, W D Atchison
Jan 1, 1984·British Journal of Pharmacology·F Henderson, I G Marshall
Jul 1, 1975·British Journal of Pharmacology·I G Marshall, R L Parsons

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