The effects of TGF beta on haemopoietic cells.

Growth Factors
J HampsonT M Dexter

Abstract

Transforming growth factor beta (TGF beta) suppresses the growth of differentiation inducible, murine IL-3-dependent multipotential cell lines but has no growth inhibitory effect upon an IL-3-independent (leukaemic) cell line arising from one of them, nor on IL-3-dependent cell lines that are unable to undergo differentiation. TGF beta inhibits in vitro colony formation by normal multipotential haemopoietic progenitor cells. Bipotential progenitors recruited by GM-CSF are, however, more resistant to the inhibitory effects of TGF beta, whereas progenitors recruited by the lineage restricted factor, M-CSF, are sensitive to the inhibitory effects. These data indicate that responsiveness to TGF beta is differentiation linked and studies with the cell lines suggest that response (or lack of response is not determined solely by levels of expression of TGF beta receptors. Furthermore, the effects of TGF beta 2 on haemopoietic progenitors are very similar to those induced by TGF beta.

References

Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A B RobertsJ H Kehrl
Mar 17, 1988·Nature·M B Sporn, A B Roberts
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T MasuiC C Harris
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S M WahlM B Sporn
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R A Ignotz, J Massagué
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J MassaguéB Nadal-Ginard
Oct 1, 1988·British Journal of Haematology·M HinoF Takaku
May 29, 1986·Biochemical and Biophysical Research Communications·M Fràter-SchröderP Böhlen
Oct 29, 1987·Biochemical and Biophysical Research Communications·J E RanchalisD R Twardzik
Jan 19, 1984·Nature·M C FungI G Young
Jun 1, 1984·The Journal of Experimental Medicine·J W VisserA M de Leeuw
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C A FrolikM B Sporn
Oct 1, 1980·The Journal of Experimental Medicine·T M DexterD Metcalf
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A B RobertsM B Sporn

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Citations

Jan 1, 1992·International Journal of Cell Cloning·J R KellerF W Ruscetti
Dec 1, 1989·Cancer Metastasis Reviews·C P Daniel, T M Dexter
Jan 1, 1990·Progress in Growth Factor Research·G J Graham, I B Pragnell
Feb 26, 1998·Leukemia & Lymphoma·M M Robledo, J Teixidó
Jul 1, 1992·Baillière's Clinical Haematology·E G Wright, I B Pragnell
Jan 9, 1998·Baillière's Clinical Haematology·R E Ploemacher
Mar 29, 1990·Nature·T M Dexter, H White
Mar 12, 1990·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T M DexterI L Ponting
Jan 1, 1991·Growth Factors·A MigdalskaT M Dexter

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