Abstract
We describe here some immunomodulatory effects of thalidomide on autoimmune-prone mice. The highly increased synthesis of splenic IgM in NZB mice, of splenic and lymph node IgG of different subclasses in MRL/n mice, and of splenic and lymph node IgG1 in MRL/lpr mice was markedly inhibited by thalidomide treatment. After a single treatment with 3 mg of thalidomide, the following changes were observed in NZB mice: (i) an initial decrease in the numbers of large CD5+ microhigh, and in the numbers of total CD5+ micro-, CD5- microhigh, CD5+ microhigh lymphocyte populations of the pleural cavity followed by a late increase in the numbers of large cells of the three cell populations; (ii) a consistent increase in the numbers of a CD5low microlow pleural lymphoid population; (iii) a consistent reduction in the numbers of splenic large CD5+ B cells and an oscillatory increase in the number of cells with CD5- phenotype; (iv) a late reduction in the numbers of splenic total CD5+ B cells. These results are consistent with the notion that thalidomide controls a disease-associated expansion of B cells in autoimmune prone mouse strains through a stimulatory effect of the drug on the immune system.
References
Jan 29, 1977·Lancet·J Eravelly, M F Waters
Mar 24, 1979·British Medical Journal·M F WatersJ E Lennard-Jones
Aug 1, 1976·European Journal of Immunology·E GronowiczF Melchers
May 4, 1992·Annals of the New York Academy of Sciences·M A MarcosA Coutinho
Jan 9, 1992·The New England Journal of Medicine·J M Dwyer
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·F VarelaA Coutinho
Nov 1, 1990·Journal of the American Academy of Dermatology·M H RustinT W Robinson
Aug 1, 1989·Immunological Reviews·F RossiM D Kazatchkine
Aug 11, 1973·Lancet·L LevyR I Freedman
Nov 24, 1973·Lancet·C L Crawford
Dec 20, 1974·Nature·A J Cunningham
Jan 1, 1981·Immunological Reviews·A N Theofilopoulos, F J Dixon
Oct 1, 1984·Arthritis and Rheumatism·O Gutiérrez-Rodríguez
Jan 1, 1983·The Journal of Experimental Medicine·K HayakawaL A Herzenberg
Apr 1, 1983·The British Journal of Dermatology·J KnopE Macher
Jul 1, 1982·The British Journal of Dermatology·B NaafsW R Faber
May 1, 1980·Archives of Dermatology·H van den Broek
May 1, 1980·Vestnik dermatologii i venerologii·V G KoliadenkoN M Shupen'ko
Citations
Aug 28, 2012·Rheumatology·Sang-Won LeeBeom Seok Kim
Jan 17, 2012·International Immunopharmacology·E ShannonP Stagg
Jun 30, 2000·Toxicology and Applied Pharmacology·N A KarrowK L White
Apr 26, 2008·International Reviews of Immunology·Taraneh Paravar, Delphine J Lee