PMID: 9169298May 1, 1997Paper

The effects of the 5-HT1A agonist flesinoxan, in three paradigms for assessing antidepressant potential in the rat

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
J F CryanB E Leonard

Abstract

5-HT1A receptor agonists have been shown to be effective clinically in the treatment of depression and anxiety. Flesinoxan is an example which is highly selective for the 5-HT1A receptor subtype. The objective of this study was to appraise the antidepressant potential of flesinoxan (1 and 3 mg/kg s.c.) in three tests which are indicative of antidepressant activity. These are (1) the forced swim test, following sub-acute administration, (2) 'open field' activity in the olfactory bulbectomised (OB) rat, following chronic administration, and (3) 8-OH-DPAT-induced hypothemia following chronic treatment. Both doses of flesinoxan significantly reduced the immobility time in the sham and OB groups when compared to their respective controls. In the 'open field', there was a significant increase in the ambulation of the OB control group. The higher dose of flesinoxan significantly reduced this deficit. In addition both doses of flesinoxan significantly attenuated the 8-OH-DPAT-induced hypothermic response. These effects of flesinoxan are quantitatively similar to those seen following the chronic administration of antidepressants. These studies illustrate the potential antidepressant properties of flesinoxan, and hence further emphasise ...Continue Reading

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Citations

Nov 26, 2010·Psychopharmacology·Gregory V Carr, Irwin Lucki
Mar 10, 2000·European Journal of Pharmacology·J F CryanB E Leonard
Mar 19, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·C McGrath, T R Norman
Oct 16, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·N HaddjeriP Blier
Jul 18, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·I C van der SandtD D Breimer
Feb 29, 2016·Pharmacological Reports : PR·Karolina PytkaBarbara Filipek
Apr 13, 2010·Frontiers in Neuroendocrinology·J M KoolhaasB Buwalda
Aug 6, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T G Dinan, J F Cryan
Nov 5, 2014·British Journal of Pharmacology·Maria Grazia CascioRoger G Pertwee
Aug 12, 2014·Behavioural Brain Research·Stefano Puglisi-Allegra, Diego Andolina
Oct 31, 2002·Human Psychopharmacology·John F. Cryan, Brian E. Leonard
Jun 1, 2005·Neuroscience and Biobehavioral Reviews·Cai Song, Brian E Leonard
Oct 5, 2007·Brain, Behavior and Evolution·Jaap M KoolhaasKees van Reenen

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