PMID: 3191941Jan 1, 1988

The effects of the 5 HT2 antagonist ketanserin in adult atopic asthma

European Journal of Clinical Pharmacology
D J StottS G Ball

Abstract

We have studied eight adult atopic asthmatic patients in a randomized double-blind, placebo-controlled, cross-over trial in order to examine the effects of the 5 HT2 antagonist ketanserin on airways function (FEV1, FVC, V50(chi), and V25(pi]. Ketanserin did not significantly change resting bronchomotor tone. Treadmill exercise caused a similar maximal percentage fall in FEV1 after both drug [16.8 (3.7)%] and placebo [19.2 (4.2)%]; ketanserin did not significantly attenuate bronchoconstriction, measured over a 20-min period after exercise. These results suggest that 5 HT2 receptors do not play a major role in the control of resting bronchomotor tone or in exercise-induced bronchoconstriction in adult atopic asthmatic patients.

Citations

Jan 1, 1985·Journal of Cardiovascular Pharmacology·F De Clerck, B Xhonneux
Jan 1, 1987·Journal of Cardiovascular Pharmacology·J I RobertsonS G Ball
Jul 1, 1985·Clinical Allergy·S Y SoS Kwan
Nov 1, 1987·British Journal of Clinical Pharmacology·R DonnellyJ L Reid
Oct 1, 1986·British Journal of Clinical Pharmacology·M J CushleyS T Holgate
Feb 1, 1985·Allergy·P Tønnesen
Jan 1, 1966·Journal of Applied Physiology·H J ColebatchJ A Nadel
May 1, 1981·Thorax·P J BarnesC T Dollery
Apr 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J R ShellerJ A Nadel
Jun 4, 1981·The New England Journal of Medicine·K A KnauerJ E Fish

Related Concepts

Expiratory Airflow
Bronchospasm, Exercise-Induced
Dermatitis, Atopic
R-41,468
Bronchoconstriction
Teens
Asthma
Atopy
Serotonin 5-HT2 Receptor Antagonists
Ketanserin

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