PMID: 3191941Jan 1, 1988

The effects of the 5 HT2 antagonist ketanserin in adult atopic asthma

European Journal of Clinical Pharmacology
D J StottS G Ball


We have studied eight adult atopic asthmatic patients in a randomized double-blind, placebo-controlled, cross-over trial in order to examine the effects of the 5 HT2 antagonist ketanserin on airways function (FEV1, FVC, V50(chi), and V25(pi]. Ketanserin did not significantly change resting bronchomotor tone. Treadmill exercise caused a similar maximal percentage fall in FEV1 after both drug [16.8 (3.7)%] and placebo [19.2 (4.2)%]; ketanserin did not significantly attenuate bronchoconstriction, measured over a 20-min period after exercise. These results suggest that 5 HT2 receptors do not play a major role in the control of resting bronchomotor tone or in exercise-induced bronchoconstriction in adult atopic asthmatic patients.


Jan 1, 1985·Journal of Cardiovascular Pharmacology·F De Clerck, B Xhonneux
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Related Concepts

Expiratory Airflow
Bronchospasm, Exercise-Induced
Dermatitis, Atopic
Serotonin 5-HT2 Receptor Antagonists

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