PMID: 6159130Jun 1, 1980Paper

The effects of the antagonists of the renin-angiotensin system on cardiovascular response to lower-body subatmospheric pressure in the anaesthetized cat

Clinical Science
S A AdigunR Hatton


1. Lower-body subatmospheric (negative) pressure led to a prompt reduction in central venous pressure and arterial blood pressure. Arterial blood pressure was then restored within 30 s and there was a tachycardia. These reflex responses have been used to investigate the role angiotensin plays in blood pressure control. 2. The initial plasma renin activity (2.9 ng of angiotensin I h-1 ml-1) did not change during the brief lowering of pressure. Before pressure was lowered neither the angiotensin-converting enzyme inhibitor nor a competitive antagonist, [Sar1, Ala8]-angiotensin II, lowered arterial pressure. 3. Nevertheless, after inhibition of the renin-angiotensin system by these agents, the reduction in blood pressure induced by lower-body negative pressure became greater and the blood pressure recovery was impaired. 4. The findings suggest that angiotensin, at a blood concentration which has no direct effect on blood pressure, interacts with the sympathetic nervous system to maintain arterial blood pressure.


Dec 1, 1982·British Journal of Clinical Pharmacology·A SturaniP Zucchelli
Oct 21, 1983·Pharmaceutisch Weekblad. Scientific Edition·P A Van ZwietenP B Timmermans
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·A P NiarchosJ H Laragh
Jun 1, 1981·Journal of Autonomic Pharmacology·M A Petty, J L Reid

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