PMID: 8972634Dec 1, 1996Paper

The effects of the broadband UVA radiation on myeloid leukemia cells: the possible role of protein kinase C in mediation of UVA-induced effects

Photochemistry and Photobiology
Dariusz LeszczynskiK Leszczynski

Abstract

We examined the effects of broadband UVA radiation (320-400 nm) on a rat myeloid leukemia cell line-chloroma (ChL). A Phillips face tanner model HB 171/A was used as a light source. Chloroma were irradiated through a 5 mm thick glass filter that cut off all of the UVB contamination. The irradiances were measured, from 250 to 400 nm, with a well-characterized and calibrated double-grating spectroradiometer Optronic 742. The overall uncertainty of dose evaluation was estimated to be +/-15% (2 sigma). The cells were irradiated with UVA doses of 4 and 8 J/cm2 and cultured thereafter for 24 h. After this period of time, a marked decline up to 50% was observed in cell proliferation in UVA-irradiated ChL cultures. The cell proliferation decline was found to be caused by simultaneously occurring G2/M phase cell cycle arrest and apoptosis in part of the UVA-irradiated ChL population. Concomitantly, with the decline in cell proliferation, an increase was observed in the expression of the major histocompatibility (MHC) class I and II antigens. Because protein kinase C (PKC) is known to regulate cell proliferation, apoptosis and expression of MHC antigens, and because UVA was shown to regulate PKC activity/expression, we therefore examined...Continue Reading

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Citations

May 4, 2007·Cancer Cell International·Riikka Pastila, Dariusz Leszczynski
Oct 8, 1998·Reproductive Toxicology·K W WardE S Hunter
Jul 7, 2005·Photodermatology, Photoimmunology & Photomedicine·Riikka Pastila, Dariusz Leszczynski
Sep 10, 2005·Photodermatology, Photoimmunology & Photomedicine·Riikka Pastila, Dariusz Leszczynski

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