The effects of the combination of inhaled ipratropium and oral theophylline in asthma

Chest
N K Burki

Abstract

In comparison to beta-agonist drugs, which are the primary bronchodilator drugs in current use in asthma, both oral theophylline and inhaled ipratropium have a weaker bronchodilating action in asthma. Although a number of studies have shown an additive effect of ipratropium in combination with beta-agonist bronchodilator drugs in asthmatics, to our knowledge, the effects of combined treatment with ipratropium and theophylline have not been assessed. To assess whether the combination of oral theophylline and inhaled ipratropium has an additive bronchodilator effect in asthmatics. Double-blind, placebo-controlled, crossover study. Nineteen patients (8 male, 11 female) with mild-to-moderate stable asthma. Initially the optimal single oral dose of theophylline required to achieve therapeutic blood levels (10 to 20 microg/mL) was established in each patient. They then returned at varying intervals on 4 subsequent days. On each day, they received, in a random, placebo-controlled, double-blind, crossover design, one of four different therapies: oral and inhaled placebo; oral theophylline at the established optimal dose (range, 300 to 700 mg) plus inhaled placebo; oral placebo plus inhaled (40 microg) ipratropium; and the combination o...Continue Reading

References

Jul 1, 1978·British Journal of Diseases of the Chest·I M LightbodyR N Johnston
Aug 15, 1991·Annals of Internal Medicine·K WrennR S Greenberg
Apr 1, 1989·Annals of Internal Medicine·T H Rossing
Oct 1, 1985·British Journal of Diseases of the Chest·B Hockley, N M Johnson
Jan 1, 1982·The Journal of Allergy and Clinical Immunology·R E RuffinJ H Alpers

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Citations

Jun 5, 2002·Current Opinion in Allergy and Clinical Immunology·Carolyn M Kercsmar, Timothy R Myers
Jul 22, 2004·The Cochrane Database of Systematic Reviews·M WestbyP Gibson

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