PMID: 9189774Jan 1, 1997Paper

The effects of the pharmacological manipulation of postoperative intestinal motility on colonic anastomoses. An experimental study in a rat model

International Journal of Colorectal Disease
D García-OlmoD C García-Olmo

Abstract

The aim of the study was to determine the effects of pharmacological manipulation of postoperative intestinal motility on the resistance of colonic anastomoses. Seventy-one Sprague-Dawley rats were divided into three groups: Group 1 (n = 20; colonic anastomosis+1 cc of saline solution subcutaneously, daily); Group 2 (n = 29; colonic anastomosis+1.2 mg/100 g body weight metoclopramide in 1 cc subcutaneously, daily); and Group 3 (n = 22; colonic anastomosis+2 mg/100 g body weight hyoscine N-butyl-bromide in 1 cc subcutaneously, daily). Surviving rats (20 in each group) were sacrificed 4 days after surgery and adhesions were evaluated. Each segment containing an anastomosis was removed and the bursting pressure was determined. The cause of death during the early postoperative period was dehiscence in 8 cases (7 in Group 2 and 1 in Group 3). General adhesion scores in Group 2 were higher than in Group 3 (P = 0.003). The score for adhesions to the anastomosis in Group 1 was higher than in Group 2, but no statistically significant difference was found. Bursting-pressure was significantly lower in Group 2 than in other groups (P = 0.001). In all cases leakage of dye was observed at the anastomosis. The use of metoclopramide (a gastroi...Continue Reading

Citations

Apr 2, 1998·European Journal of Anaesthesiology·D C García-OlmoD García-Olmo
Jul 13, 2006·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Gokhan YagciTurgut Tufan
Mar 22, 2013·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Silvana Marques e SilvaJoão Batista de Sousa
Apr 25, 2015·American Journal of Veterinary Research·Marije RisseladaEmily Griffith
Aug 21, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S M SilvaJ B Sousa
Jun 6, 2012·Acta Cirúrgica Brasileira·Silvana Marques e SilvaJoão Batista de Sousa
Aug 3, 2011·Acta Cirúrgica Brasileira·Silvana Marques e SilvaJoão Batista de Sousa
Feb 13, 2007·Acta Cirúrgica Brasileira·Santiago Cirilo Nogueira ServinAlexandre Coutinho Teixeira de Freitas
Aug 24, 2017·Oxidative Medicine and Cellular Longevity·Guangbing WeiXuqi Li
Oct 14, 2004·Alimentary Pharmacology & Therapeutics·H Ouyang, J D Z Chen

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