The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on glucose/insulin metabolism interact with prenatal exposure to famine.

Diabetes Care
Susanne R de RooijTessa J Roseboom

Abstract

An adverse fetal environment may permanently modify the effects of specific genes on glucose tolerance, insulin secretion, and insulin sensitivity. In the present study, we assessed a possible interaction of the peroxisome proliferator-activated receptor (PPAR)-gamma2 Pro12Ala polymorphism with prenatal exposure to famine on glucose and insulin metabolism. We measured plasma glucose and insulin concentrations after an oral glucose tolerance test and determined the PPAR-gamma2 genotype among 675 term singletons born around the time of the 1944-1945 Dutch famine. A significant interaction effect between exposure to famine during midgestation and the PPAR-gamma2 Pro12Ala polymorphism was found on the prevalence of impaired glucose tolerance and type 2 diabetes. The Ala allele of the PPAR-gamma2 gene was associated with a higher prevalence of impaired glucose tolerance and type 2 diabetes but only in participants who had been prenatally exposed to famine during midgestation. Similar interactions were found for area under the curve for insulin and insulin increment ratio, which were lower for Ala carriers exposed to famine during midgestation. The effects of the PPAR-gamma2 Pro12Ala polymorphism on glucose and insulin metabolism may...Continue Reading

Citations

Feb 6, 2013·Environmental Health and Preventive Medicine·Hidekuni Inadera
Jan 12, 2011·Annual Review of Public Health·L H LumeyEzra Susser
Apr 25, 2009·PPAR Research·Weimin He
Sep 18, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·L M Berends, S E Ozanne
Sep 28, 2012·Diabetes & Metabolic Syndrome·Sunil K KotaKirtikumar D Modi
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Apr 20, 2014·International Journal of Endocrinology·Noraidatulakma AbdullahElizabeth G Holliday

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